Kamycheva Elena, Goto Tadahiro, Camargo Carlos A
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 125 Nashua St, Suite 920, Boston, MA 02114, USA; Department of Geriatrics, Medical Clinic, University Hospital of North Norway, Sykehusveien 38, 9038 Tromsoe, Norway; Endocrine Research Group, Faculty of Health Sciences, Department of Clinical Medicine, UiT The Arctic University of Norway, Hansine Hansens Veg 18, 9017 Tromsoe, Norway.
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 125 Nashua St, Suite 920, Boston, MA 02114, USA; Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
Exp Gerontol. 2017 Mar;89:64-68. doi: 10.1016/j.exger.2017.01.003. Epub 2017 Jan 16.
Telomeres are nucleotide sequences, and their function is to maintain cell surveillance. Exaggeration of the attrition rate of leukocyte telomere length (LTL) may result in genomic instability and tumorigenesis. Celiac disease (CD), an autoimmune inflammation of small intestine, has increasing prevalence in the elderly and may lead to lymphomas and gastrointestinal malignancies. We used nationally-representative datasets from the U.S. National Health and Nutrition Examination Survey (NHANES) to investigate if CD autoimmunity in older adults (age≥50years) is associated with shorter LTL.
Our study included 3939 subjects, where 25 subjects (mean age 65years) were CD seropositive and 3914 (mean age 64years) were CD seronegative. CD seropositive subjects had shorter LTL than CD seronegative subjects (P<0.001). In the linear regression model, CD seropositivity was significantly associated with 0.25kb pairs decrease in LTL length (P<0.001), adjusted for age, sex, race/ethnicity, serum ferritin and folate, and ratio of family income to poverty.
In a nationally-representative population of adults age≥50years, CD seropositivity is significantly associated with shorter LTL, independently of age, sex, race/ethnicity, serum ferritin and folate, and socioeconomic status. This supports the enhanced telomere attrition in of CD seropositive adults.
端粒是核苷酸序列，其功能是维持细胞监测。白细胞端粒长度（LTL）损耗率的增加可能导致基因组不稳定和肿瘤发生。乳糜泻（CD）是一种小肠自身免疫性炎症，在老年人中的患病率不断上升，可能导致淋巴瘤和胃肠道恶性肿瘤。我们使用来自美国国家健康和营养检查调查（NHANES）的全国代表性数据集，以调查老年人（年龄≥50岁）中的CD自身免疫是否与较短的LTL相关。
我们的研究纳入了3939名受试者，其中25名受试者（平均年龄65岁）CD血清学呈阳性，3914名（平均年龄64岁）CD血清学呈阴性。CD血清学呈阳性的受试者的LTL比CD血清学呈阴性的受试者短（P<0.001）。在线性回归模型中，经年龄、性别、种族/民族、血清铁蛋白和叶酸以及家庭收入与贫困比率调整后，CD血清学阳性与LTL长度减少0.25kb对显著相关（P<0.001）。
在年龄≥50岁的全国代表性成年人中，CD血清学阳性与较短的LTL显著相关，且独立于年龄、性别、种族/民族、血清铁蛋白和叶酸以及社会经济地位。这支持了CD血清学阳性成年人中端粒损耗的增加。
