Myers Peter S, McNeely Marie E, Koller Jonathan M, Earhart Gammon M, Campbell Meghan C
Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
J Parkinsons Dis. 2017;7(1):149-157. doi: 10.3233/JPD-161029.
Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG.
To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-).
Sixty-three participants were divided into two groups, FOG+ (n = 25) and FOG- (n = 38), based on the New Freezing of Gait Questionnaire. Cognitive assessment included Trail Making, Stroop, Verbal Fluency, and Go-NoGo executive function tasks. All participants completed structural T1- and T2-weighted MRI scans. Imaging data were processed with FreeSurfer and the Spatially Unbiased Infratentorial toolbox to segment the cerebellum into individual lobules.
FOG+ performed significantly worse on phonemic verbal fluency (F(1, 22) = 7.06, p = 0.01) as well as the Go-NoGo task (F(1, 22) = 9.00, p = 0.004). We found no differences in cerebellar volumes between groups (F(4, 55) = 1.42, p = 0.24), but there were significant relationships between verbal fluency measures and lobule volumes in FOG-.
These findings underscore the need for longitudinal studies to better characterize potential changes in cerebellar volume, cognitive function, and functional connectivity between people with PD with and without FOG.
冻结步态（FOG）影响约50%的帕金森病（PD）患者，对生活质量产生影响，并给患者及其照料者带来经济和情感压力。患有PD和FOG的患者在运动适应和认知方面的缺陷与小脑病变患者相似，这表明小脑可能在FOG中发挥作用。
研究伴有（FOG+）和不伴有FOG（FOG-）的PD患者小脑体积的潜在差异及其与认知的关系。
根据新的冻结步态问卷，将63名参与者分为两组，FOG+组（n = 25）和FOG-组（n = 38）。认知评估包括连线测验、斯特鲁普测验、言语流畅性测验和停止信号执行功能任务。所有参与者均完成了结构T1加权和T2加权MRI扫描。使用FreeSurfer和无偏倚幕下空间工具箱对成像数据进行处理，将小脑分割为各个小叶。
FOG+组在音素言语流畅性（F(1, 22) = 7.06，p = 0.01）以及停止信号任务（F(1, 22) = 9.00，p = 0.004）上的表现明显更差。我们发现两组之间的小脑体积没有差异（F(4, 55) = 1.42，p = 0.24），但在FOG-组中，言语流畅性测量与小叶体积之间存在显著关系。
这些发现强调了进行纵向研究的必要性，以更好地表征伴有和不伴有FOG的PD患者在小脑体积、认知功能和功能连接方面的潜在变化。
