Lei Man-Kit, Beach Steven R H, Dogan Meeshanthini V, Philibert Robert A
Center for Family Research, University of Georgia, Athens, Georgia.
Department of Sociology, University of Georgia, Athens, Georgia.
Am J Addict. 2017 Mar;26(2):129-135. doi: 10.1111/ajad.12502. Epub 2017 Jan 20.
Smoking is known to increase biological age. However, whether this process is reversible through smoking cessation is not known. In this pilot study, we attempt to determine whether smoking cessation reduces biological age.
We conducted regression analyses of methylation data from 22 subjects, as they entered and exited inpatient substance use treatment, to determine change in biological age, as indicated by the deviation of their methylomic age from chronological age across two time points.
We found that, as compared to those subjects who did not stop smoking, subjects who significantly decreased their smoking consumption over a 1 month time period exhibited a marked reduction in methylomic age.
The rapid and substantial reversal of accelerated aging associated with successful smoking cessation suggests that it can reverse well-known smoking effects on methylomic aging. This preliminary finding can be readily examined in other, larger data sets, and if replicated, this observation may provide smokers with yet another good reason to quit smoking.
Successful smoking cessation makes patients appear biologically younger than they were at baseline, and to do so quite rapidly. In today's youth driven society, our observations may serve as a powerful impetus for some to quit smoking. (Am J Addict 2017;26:129-135).
众所周知，吸烟会增加生物学年龄。然而，尚不清楚通过戒烟这一过程是否可逆。在这项初步研究中，我们试图确定戒烟是否能降低生物学年龄。
我们对22名受试者在进入和离开住院物质使用治疗时的甲基化数据进行回归分析，以确定生物学年龄的变化，这由两个时间点上他们的甲基化组年龄与实际年龄的偏差表示。
我们发现，与未戒烟的受试者相比，在1个月时间内吸烟量显著减少的受试者甲基化组年龄显著降低。
与成功戒烟相关的加速衰老的快速且显著逆转表明，戒烟可以逆转吸烟对甲基化组衰老的已知影响。这一初步发现可以在其他更大的数据集中轻松检验，如果得到重复验证，这一观察结果可能为吸烟者提供另一个戒烟的充分理由。
成功戒烟使患者在生物学上比基线时显得更年轻，而且速度相当快。在当今以年轻人为主导的社会中，我们的观察结果可能成为一些人戒烟的强大动力。（《美国成瘾杂志》2017年；26:129 - 135）
