同源结构域相互作用蛋白激酶2（HIPK2）：一种有前景的抗癌治疗靶点。
Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.
作者信息
Feng Yuanyuan, Zhou Lihong, Sun Xiaoting, Li Qi
机构信息
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
出版信息
Oncotarget. 2017 Mar 21;8(12):20452-20461. doi: 10.18632/oncotarget.14723.
The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a "caretaker" gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity.
HIPK2（丝氨酸/苏氨酸同源结构域相互作用蛋白激酶2）是一种“守护者”基因，其失活会增加肿瘤发生能力，而其激活则会抑制肿瘤生长。本报告综述了HIPK2的抗肿瘤机制，包括促进细胞凋亡、在缺氧条件下抑制血管生成、防止肿瘤侵袭/转移以及减弱癌症中的多药耐药性。此外，我们总结了可能增加HIPK2活性的条件或因素。
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