Sun Hongmei, Xue Guanhua, Yan Chao, Li Shaoli, Zhao Hanqing, Feng Yanling, Wang Liqiong
Department of Bacteriology, Capital Institute of Pediatrics, Chaoyang District, Beijing, China.
PLoS One. 2017 Jan 20;12(1):e0170253. doi: 10.1371/journal.pone.0170253. eCollection 2017.
The molecular characteristics of 480 Mycoplasma pneumoniae polymerase chain reaction-positive specimens (331 were previously reported and 149 were newly reported) collected from pediatric patients in Beijing, China, between 2003 and 2015 were analyzed. Genotype M4-5-7-2/P1 were the most prevalent across the 13-year study period, although the isolation and mutation rates for this genotype varied between the periods 2003-2007, 2008-2013, and 2014-2015. In addition, there was a close association between the M4-5-7-2 genotype and macrolide resistance.
对2003年至2015年间在中国北京收集的480份肺炎支原体聚合酶链反应阳性标本（其中331份为先前报道，149份为新报道）的分子特征进行了分析。基因型M4-5-7-2/P1在13年的研究期间最为普遍，尽管该基因型在2003-2007年、2008-2013年和2014-2015年期间的分离率和突变率有所不同。此外，M4-5-7-2基因型与大环内酯类耐药性之间存在密切关联。
