Ono T, Wada O
Nihon Eiseigaku Zasshi. 1989 Aug;44(3):748-55. doi: 10.1265/jjh.44.748.
To determine whether lithium deficiency has an effect on lever-press avoidance behavior, low lithium diets were given to mice and the effects of these diets on conditioned lever press avoidance response were compared with that of a commercial diet containing 110 ng Li/g diet. Three low-lithium diets were prepared in this experiment and the lithium contents of the diets were 6.6, 36.6 and 76.6 ng Li/g diet. The mice used in this experiment had been maintained on a practical diet and trained by Sidman's situation previously. After checking that the conditioned response was established, they were divided into four groups. Three groups of mice each were given one of the low lithium diets, indicated above, and these were assigned into the lithium-deficient groups. Some mice were given the practical diet and this group was used as controls. The avoidance behavior was analyzed by the method reported previously by the authors. After changing the diet to a low-lithium one, the avoidance behavior was significantly suppressed in lithium-deficient groups and this appeared to be proportional to the level of lithium deficiency in the diet. Furthermore, this suppression in the avoidance behavior was recovered by lithium supplementation in the same experimental diet. These findings suggest that low-lithium intake may suppress acquired avoidance behavior in mice.
为了确定锂缺乏是否对杠杆按压回避行为有影响，给小鼠喂食低锂饮食，并将这些饮食对条件性杠杆按压回避反应的影响与含有110 ng Li/g饮食的商业饮食的影响进行比较。本实验制备了三种低锂饮食，其锂含量分别为6.6、36.6和76.6 ng Li/g饮食。本实验中使用的小鼠此前一直食用常规饮食，并通过西德曼情境进行训练。在确认条件反应建立后，将它们分成四组。每组三只小鼠分别喂食上述低锂饮食之一，这些小鼠被归为锂缺乏组。一些小鼠喂食常规饮食，该组用作对照组。采用作者之前报道的方法分析回避行为。将饮食换成低锂饮食后，锂缺乏组的回避行为受到显著抑制，这似乎与饮食中的锂缺乏水平成正比。此外，在相同的实验饮食中补充锂后，回避行为的这种抑制得到恢复。这些发现表明，低锂摄入可能会抑制小鼠后天获得的回避行为。
