Klemfuss H, Schrauzer G N
Veterans Affairs Medical Center, San Diego, CA, USA.
Biol Trace Elem Res. 1995 May;48(2):131-9. doi: 10.1007/BF02789187.
To demonstrate whether nutritional lithium deficiency is associated with behavioral changes, male Sprague-Dawley rats were placed on a lithium-deficient diet (Li content < .01 ppm). A lithium-deprived group, receiving drinking water containing 31 microM NaCl, were compared to a control group receiving drinking water containing 31 microM LiCl. Growth and general appearance were the same in both groups. However, lithium-deficient animals demonstrated decreased aggression in social interactions with other rats and also in response to handling. The phase of wheel-running activity was delayed by 0.8 h and exhibited decreased amplitude (p < .05). Other behaviors, including acquisition and retention of a passive avoidance response, were unaffected by lithium deprivation.
为了证明营养性锂缺乏是否与行为变化有关，将雄性斯普拉格-道利大鼠置于缺锂饮食（锂含量<0.01 ppm）中。将接受含31 microM氯化钠饮用水的缺锂组与接受含31 microM氯化锂饮用水的对照组进行比较。两组的生长和总体外观相同。然而，缺锂动物在与其他大鼠的社交互动以及对处理的反应中表现出攻击性降低。轮转活动阶段延迟了0.8小时，并且振幅降低（p<0.05）。其他行为，包括被动回避反应的获得和保持，不受锂缺乏的影响。
