急性中心性浆液性脉络膜视网膜病变的一种新型标志物：硫醇/二硫键稳态
A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis.
作者信息
Altinkaynak Hasan, Kurkcuoglu Piraye Zeynep, Caglayan Mehtap, Yorgun Mücella Arıkan, Yuksel Nilay, Kosekahya Pınar, Koca Cemile, Toklu Yasin
机构信息
Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
Department of Ophthalmology, World Eye Hospital, Ankara, Turkey.
出版信息
Int Ophthalmol. 2018 Feb;38(1):175-181. doi: 10.1007/s10792-017-0444-3. Epub 2017 Jan 21.
PURPOSE
The aim of this study was to compare dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamic thiol/disulfide homeostasis.
METHODS
Fifty-one patients with acute CSCR (study group) and 65 healthy individuals (control group) were enrolled in this study. Diagnosis of acute CSCR was made clinically and using spectral-domain RTVue OCT (optical coherence tomography) (Optovue, Fremont, CA). Fluorescein angiography confirmed the diagnosis of acute CSCR in all subjects. Total thiol, native thiol, disulfide amount, and native thiol/disulfide ratio (TDR) were calculated in the blood samples.
RESULTS
Mean total thiol, native thiol, and native TDR values were lower in patients with acute CSCR (364.2 ± 14.1, 326.4 ± 13.2, 17.14 ± 1.9, respectively) than in healthy eyes (441.2 ± 16.3, 398.5 ± 16.4, 22.70 ± 2.15, respectively; mean total thiol, p = 0.017; native thiol, p = 0.011; native TDR, p = 0.031).
CONCLUSIONS
Total thiol, native thiol, and native TDR were significantly lower statistically in patients with acute CSCR when compared with healthy controls.
目的
本研究旨在通过一种新型自动化检测方法测定动态硫醇/二硫键稳态，比较急性中心性浆液性脉络膜视网膜病变（CSCR）患者的动态硫醇/二硫键稳态状况。
方法
本研究纳入了51例急性CSCR患者（研究组）和65名健康个体（对照组）。急性CSCR通过临床诊断及使用光谱域RTVue OCT（光学相干断层扫描）（Optovue，弗里蒙特，加利福尼亚州）进行诊断。荧光素血管造影术在所有受试者中均证实了急性CSCR的诊断。计算血样中的总硫醇、天然硫醇、二硫键含量及天然硫醇/二硫键比率（TDR）。
结果
急性CSCR患者的平均总硫醇、天然硫醇及天然TDR值（分别为364.2±14.1、326.4±13.2、17.14±1.9）低于健康受试者（分别为441.2±16.3、398.5±16.4、22.70±2.15；平均总硫醇，p = 0.017；天然硫醇，p = 0.011；天然TDR，p = 0.031）。
结论
与健康对照组相比，急性CSCR患者的总硫醇、天然硫醇及天然TDR在统计学上显著更低。
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