基于三八面体金纳米结构的活细胞中一氧化氮的比率表面增强拉曼散射成像及选择性生物传感
Ratiometric SERS imaging and selective biosensing of nitric oxide in live cells based on trisoctahedral gold nanostructures.
作者信息
Xu Qiao, Liu Wei, Li Li, Zhou Feng, Zhou Jian, Tian Yang
机构信息
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.
出版信息
Chem Commun (Camb). 2017 Feb 7;53(11):1880-1883. doi: 10.1039/c6cc09563a. Epub 2017 Jan 23.
Herein, a ratiometric SERS probe was created for monitoring nitric oxide (NO) by designing a novel molecule, 3,4-diaminobenzene-thiol, and immobilizing this molecule onto trisoctahedral gold nanostructures with superior SERS capability. The established probe possessed good selectivity and biocompatibility, high sensitivity and accuracy, thus enabling imaging and biosensing of NO in live cells.
在此，通过设计一种新型分子3,4-二氨基苯硫醇，并将该分子固定在具有优异表面增强拉曼散射（SERS）能力的三八面体金纳米结构上，制备了一种用于监测一氧化氮（NO）的比率型SERS探针。所建立的探针具有良好的选择性和生物相容性、高灵敏度和准确性，从而能够对活细胞中的NO进行成像和生物传感。
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