IEEE Trans Neural Syst Rehabil Eng. 2017 Sep;25(9):1440-1452. doi: 10.1109/TNSRE.2016.2629461. Epub 2016 Nov 16.
We have developed a stretchablemicroneedle electrode array (sMEA) to stimulate andmeasure the electrical activity of muscle across multiple sites. The technology provides the signal fidelity and spatial resolution of intramuscular electrodesacross a large area of tissue. Our sMEA is composed of a polydimethylsiloxane (PDMS) substrate, conductive-PDMS traces, and stainless-steel penetrating electrodes. The traces and microneedles maintain a resistance of less than 10 [Formula: see text] when stretched up to a ~63% tensile strain, which allows for the full range of physiological motion of felinemuscle. The device and its constituent materials are cytocompatible for at least 28 days in vivo. When implanted in vivo, the device measures electromyographic (EMG) activity with clear compound motor unit action potentials. The sMEA also maintains a stable connection with moving muscle while electrically stimulating the tissue. This technology has direct application to wearable sensors, neuroprostheses, and electrophysiological studies of animals and humans.
我们开发了一种可拉伸的微针电极阵列（sMEA），用于刺激和测量肌肉在多个部位的电活动。该技术在大面积组织上提供了类似于肌内电极的信号保真度和空间分辨率。我们的 sMEA 由聚二甲基硅氧烷（PDMS）基底、导电 PDMS 迹线和不锈钢穿透电极组成。当拉伸至约 63%的拉伸应变时，迹线和微针的电阻保持在 10 [Formula: see text] 以下，这允许猫科动物肌肉进行全范围的生理运动。该设备及其组成材料在体内至少 28 天具有细胞相容性。当植入体内时，该设备可测量肌电图（EMG）活动，并清晰显示复合运动单位动作电位。sMEA 在对组织进行电刺激时，还能与移动的肌肉保持稳定的连接。这项技术直接适用于可穿戴传感器、神经假体以及动物和人类的电生理研究。
