Garcia-Junco-Clemente Pablo, Ikrar Taruna, Tring Elaine, Xu Xiangmin, Ringach Dario L, Trachtenberg Joshua T
Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, and CIBERNED, Seville, Spain.
Nat Neurosci. 2017 Mar;20(3):389-392. doi: 10.1038/nn.4483. Epub 2017 Jan 23.
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.
推挽是兴奋性皮质回路的一种典型计算方式。相比之下，我们在额叶皮质中发现了一种拉推抑制性回路，它起源于表达血管活性肠肽（VIP）的中间神经元。在觉醒过程中，VIP细胞迅速且直接地抑制锥体神经元；VIP细胞还通过平行去抑制间接兴奋这些锥体神经元。因此，觉醒对兴奋性神经元施加了一种反馈性的拉推影响——这与前馈输入的典型推挽方式相反。
