双重改性西米淀粉/κ-卡拉胶薄膜的功能特性：替代明胶的药用胶囊材料。
Functional properties of dually modified sago starch/κ-carrageenan films: An alternative to gelatin in pharmaceutical capsules.
机构信息
Department of Chemical Engineering, Shahrood Branch, Islamic Azad University, Shahrood, Iran.
Food Science and Technology Department, Science and Research Branch, Islamic Azad University, Tehran, Iran.
出版信息
Carbohydr Polym. 2017 Mar 15;160:43-51. doi: 10.1016/j.carbpol.2016.12.042. Epub 2016 Dec 20.
The aim of this study was development a composite film based on sago starch and κ-carrageenan to find a gelatin alternative in the pharmaceutical capsules processing. Hydrolyzed-Hydroxypropylated (dually modified) sago starch was mixed with κ-carrageenan (0.25, 0.5, 0.75, and 1%). The drying kinetics, thermomechanical, physicochemical, and barrier properties of composite films were estimated and compared with bovine gelatin. Results show that drying kinetics and mechanical properties of the composite films were comparable to those of gelatin. The water vapor permeability and moisture content of the composite films were lower than those of gelatin. The solubility of the composite films was higher than that of gelatin, and the composite films were more stable at higher relative humidity than were the gelatin films. These results show that dually modified sago starch in combination with κ-carrageenan has properties similar to those of gelatin, thus proposed system can be used in pharmaceutical capsules processes.
本研究旨在开发一种基于西米淀粉和κ-卡拉胶的复合膜，以寻找替代明胶的制药胶囊加工材料。将羟丙基水解（双重改性）西米淀粉与κ-卡拉胶（0.25、0.5、0.75 和 1%）混合。对复合膜的干燥动力学、热机械、物理化学和阻隔性能进行了评估，并与牛明胶进行了比较。结果表明，复合膜的干燥动力学和力学性能与明胶相当。复合膜的水蒸气透过率和水分含量均低于明胶。复合膜的溶解度高于明胶，在较高的相对湿度下，复合膜比明胶膜更稳定。这些结果表明，双重改性的西米淀粉与κ-卡拉胶结合具有类似于明胶的性质，因此所提出的系统可用于制药胶囊工艺。
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