College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China.
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China.
Int J Biol Macromol. 2023 Jul 31;244:125427. doi: 10.1016/j.ijbiomac.2023.125427. Epub 2023 Jun 15.
Although gelatin has good characteristics in preparing soft capsules, its noticeable shortcomings force researchers to further develop substitutes for gelatin soft capsules. In this paper, sodium alginate (SA), carboxymethyl starch (CMS) and κ-carrageenan (κ-C) were used as matrix materials, and the formula of the co-blended solutions was screened through rheological method. In addition, films of the different blends were characterized by thermogravimetry analysis, SEM, FTIR, X-ray, water contact angle and mechanical properties. The results showed that κ-C had strong interaction with CMS and SA, and the mechanical properties of capsule shell were greatly improved by the addition of κ-C. When the ratio of CMS/SA/κ-C was 2:0.5:1.5, the microstructure of the films was more dense and uniform. In addition, this formula had the best mechanical properties and adhesion properties, and was more suitable for the production of soft capsules. Finally, a novel plant soft capsule was successfully prepared by dropping method, and its appearance and rupture properties met the requirements of enteric soft capsules. In simulated intestinal fluid, the soft capsules were almost completely degraded within 15 min, and they were superior to the gelatin soft capsules. Therefore, this study provides an alternative formula for preparing enteric soft capsules.
尽管明胶在制备软胶囊方面具有良好的特性，但它明显的缺点迫使研究人员进一步开发明胶软胶囊的替代品。本文以海藻酸钠（SA）、羧甲基淀粉（CMS）和κ-卡拉胶（κ-C）为基质材料，通过流变学法筛选共混溶液的配方。此外，还通过热重分析、SEM、FTIR、X 射线、水接触角和力学性能对不同共混物的薄膜进行了表征。结果表明，κ-C 与 CMS 和 SA 具有很强的相互作用，通过添加 κ-C 大大提高了胶囊壳的力学性能。当 CMS/SA/κ-C 的比例为 2:0.5:1.5 时，薄膜的微观结构更加致密均匀。此外，该配方具有最佳的力学性能和附着力，更适合软胶囊的生产。最后，通过滴制法成功制备了一种新型植物软胶囊，其外观和破裂性能符合肠溶软胶囊的要求。在模拟肠液中，软胶囊在 15 分钟内几乎完全降解，优于明胶软胶囊。因此，本研究为制备肠溶软胶囊提供了一种替代配方。
