School of Health Sciences, University of Tampere, Tampere, Finland.
Menopause. 2012 Jun;19(6):691-6. doi: 10.1097/gme.0b013e31823cc5f7.
The aim of this study was to assess whether aerobic training affects menopausal symptoms in recently postmenopausal sedentary women.
Symptomatic women aged 45 to 63 years (N = 176; 3-36 months since last menstruation) were randomly assigned to an aerobic training or a control group. The intervention included unsupervised aerobic training for 50 minutes four times weekly for 24 weeks, whereas the control group attended health lectures twice a month. Symptoms were reported twice a day using a mobile phone. The perceived disturbance of menopausal symptoms (night sweats, mood swings, irritability, depressive mood, headache, vaginal dryness, and urinary symptoms) was evaluated on a scale from 1 (low) to 5 (high). Multilevel mixed-effect ordinal regression models were based on 17,000 responses during 24 weeks.
One hundred fifty-four women continued until the end of the study (88% compliance rate). Baseline prevalence was as follows: night sweats, 50% to 60%; irritability and depression, 20% to 25%; mood swings, 25% to 30%; headache and urinary problems, 15% to 20%; and vaginal dryness, 10% to 15%. The prevalence of all symptoms except vaginal dryness decreased among intervention groups. According to multilevel mixed-effect ordinal regression analysis, night sweats and mood swings (P < 0.001) and disturbance of the mood swings (P < 0.001) and irritability (P < 0.001) were reduced more among the women in the intervention group than in the control group.
In sedentary women, aerobic training for 6 months may decrease the typical menopausal symptoms, especially night sweats, mood swings, and irritability.
本研究旨在评估有氧运动是否会影响近期绝经的久坐不动女性的绝经症状。
45 至 63 岁的有症状女性（N=176；上次月经后 3-36 个月）被随机分配到有氧运动组或对照组。干预措施包括每周 4 次、每次 50 分钟的非监督有氧运动，持续 24 周，而对照组每月参加两次健康讲座。使用手机每天报告两次症状。通过 1 分（低）至 5 分（高）的量表评估绝经症状（盗汗、情绪波动、易怒、抑郁情绪、头痛、阴道干燥和尿症状）的干扰程度。基于 24 周内的 17000 次反应，采用多级混合效应有序回归模型进行分析。
154 名女性坚持到研究结束（88%的依从率）。基线患病率如下：盗汗，50%-60%；易怒和抑郁，20%-25%；情绪波动，25%-30%；头痛和尿问题，15%-20%；阴道干燥，10%-15%。除阴道干燥外，所有症状的患病率均下降。根据多级混合效应有序回归分析，与对照组相比，干预组的盗汗和情绪波动（P<0.001）以及情绪波动和易怒的干扰程度（P<0.001）均有所降低。
在久坐不动的女性中，6 个月的有氧运动可能会减少典型的绝经症状，特别是盗汗、情绪波动和易怒。
