Sharma Sonam, Dawson Leelavathi
Department of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
Case Rep Pathol. 2017;2017:6497376. doi: 10.1155/2017/6497376. Epub 2017 Jan 2.
Tumors of thymus gland are rare and account for 0.2% to 1.5% of all the neoplasms. They constitute a heterogeneous group that has an unknown etiology and a complex as well as varied biology. This has led to difficulty in their histological classification and in predicting their prognostic and survival markers. Among them, thymic carcinoma is the most aggressive thymic epithelial tumor exhibiting cytological malignant features and a diversity of clinicopathological characteristics that can cause diagnostic dilemmas, misdiagnosis, and therapeutic challenge. We herein describe a case of a 60-year-old man who while undergoing evaluation for the cause of pancytopenia was discovered having bone marrow metastasis from an asymptomatic thymic carcinoma. Bone marrow metastasis is an extremely rare initial presentation of thymic carcinoma with only few cases reported in the literature.
胸腺肿瘤较为罕见，占所有肿瘤的0.2%至1.5%。它们是一组异质性肿瘤，病因不明，生物学特性复杂多样。这导致其组织学分类以及预测预后和生存标志物存在困难。其中，胸腺癌是最具侵袭性的胸腺上皮肿瘤，具有细胞学恶性特征和多种临床病理特征，可导致诊断困境、误诊和治疗挑战。我们在此描述一例60岁男性病例，该患者在接受全血细胞减少病因评估时，被发现患有无症状胸腺癌的骨髓转移。骨髓转移是胸腺癌极其罕见的初始表现，文献中仅报道了少数病例。
