非综合征性口腔颌面部裂隙的遗传学和基因组学病因
Genetics and genomics etiology of nonsyndromic orofacial clefts.
作者信息
Adeyemo Wasiu L, Butali Azeez
机构信息
Department of Oral and Maxillofacial Surgery College of Medicine University of Lagos Surulere Nigeria.
Department of Oral Pathology, Radiology and MedicineCollege of DentistryUniversity of IowaIowa CityIowa; Iowa Institute of Oral Health ResearchCollege of DentistryUniversity of IowaIowa CityIowa.
出版信息
Mol Genet Genomic Med. 2017 Jan 17;5(1):3-7. doi: 10.1002/mgg3.272. eCollection 2017 Jan.
Abstract
Orofacial clefts (OFC) are complex birth defects. Studies using contemporary genomic techniques, bioinformatics, and statistical analyses have led to appreciable advances in identifying the causes of syndromic forms of clefts. This commentary gives an overview of the important cleft gene discoveries found using various genomic methods and tools.
摘要
口面部裂隙（OFC）是复杂的出生缺陷。运用当代基因组技术、生物信息学和统计分析的研究，在确定综合征型腭裂病因方面取得了显著进展。本述评概述了使用各种基因组方法和工具发现的重要腭裂基因。
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