Department of Biomedical Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
Department of Chemistry, College of Chemistry and Chemical Engineering & College of Materials, Xiamen University , Xiamen 361005, China.
ACS Appl Mater Interfaces. 2017 Feb 8;9(5):4467-4474. doi: 10.1021/acsami.6b14355. Epub 2017 Jan 24.
A surface directly connects the bulk of a material to its surroundings. The ability to dynamically regulate the surface without affecting the bulk of a material holds great potential for new applications. The purpose of this work was to demonstrate that the surface can be dynamically changed using nanoparticles and oligonucleotides (ODNs) in a reversible and reiterative manner. A dual-functional nanogel was synthesized as the model of nanoparticles using miniemulsion polymerization and click chemistry. The nanogel can not only adsorb drugs for sustained drug release but also bind a surface functionalized with complementary ODNs. Importantly, hybridization reaction and ODN degradation can drive reversible and reiterative nanogel binding to the surface for dynamic change, which in principle is unlimited. Moreover, nanogel-mediated dynamic change offers the surface with the drug-releasing function for inhibiting the growth of surrounding cells. Because nanogels can be replaced by any functional nanoparticles with a diverse array of properties, nanoparticle-programmed surface change constitutes a promising platform for various applications such as drug delivery and stent implantation.
表面将材料的本体与其周围环境直接连接起来。能够在不影响材料本体的情况下动态调节表面，这为新材料的应用带来了巨大的潜力。本工作的目的是证明可以使用纳米颗粒和寡核苷酸（ODNs）以可逆和重复的方式动态改变表面。使用细乳液聚合和点击化学合成了双功能纳米凝胶作为纳米颗粒的模型。纳米凝胶不仅可以吸附药物以实现持续的药物释放，还可以与表面结合，该表面经过互补 ODNs 功能化处理。重要的是，杂交反应和 ODN 降解可以驱动纳米凝胶可逆且重复地结合到表面，从而实现动态变化，从原理上讲，这种变化是无限的。此外，纳米凝胶介导的动态变化为表面提供了释放药物的功能，从而抑制周围细胞的生长。由于纳米凝胶可以被具有各种特性的任何功能性纳米颗粒所取代，因此纳米颗粒编程的表面变化构成了用于药物输送和支架植入等各种应用的有前途的平台。
