Adler I D, Ingwersen I
GSF-Institut für Säugetiergenetik, Neuherberg, F.R.G.
Mutat Res. 1989 Nov;224(3):343-5. doi: 10.1016/0165-1218(89)90176-6.
The chemical caprolactam (CAP) was tested for induction of chromosomal aberrations in bone marrow of male and female 1C3F1 mice at a single dose of 1000 mg/kg by oral intubation of an aqueous solution at a volume of 0.1 ml/10 g of body weight. Bone marrow was sampled from groups of 10 animals 24, 30 and 48 h after treatment. CAP did not produce chromosomal aberrations under the present experimental conditions. At the same time, benzo[a]pyrene, used as a positive control, significantly increased the aberration rates at a dose of 63 mg/kg.
