Bermudez E, Smith-Oliver T, Delehanty L L
Department of Genetic Toxicology, Chemical Industry Institute of Toxicology, Research Triangle Park, NC.
Mutat Res. 1989 Nov;224(3):361-4. doi: 10.1016/0165-1218(89)90180-8.
Benzoin (ZOIN) and caprolactam (CAP) were administered by gavage to Fischer 344 rats at a dose of 750 mg/kg and the hepatocytes isolated 12, 24 or 48 h after treatment. The isolated hepatocytes were subsequently examined for the induction of DNA-strand breaks (SB) and unscheduled DNA synthesis (UDS). Neither ZOIN nor CAP induced SB or UDS in hepatocytes, however ZOIN did induce an increase in the fraction of cells in S-phase 24 h after treatment. These results correlate well with the observed lack of carcinogenicity of these compounds.
将安息香（ZOIN）和己内酰胺（CAP）以750毫克/千克的剂量通过灌胃给予Fischer 344大鼠，并在治疗后12、24或48小时分离肝细胞。随后检查分离出的肝细胞的DNA链断裂（SB）诱导情况和非程序性DNA合成（UDS）。ZOIN和CAP均未诱导肝细胞中的SB或UDS，然而，ZOIN确实在治疗后24小时诱导S期细胞比例增加。这些结果与观察到的这些化合物缺乏致癌性密切相关。
