Working P K
Department of Genetic Toxicology, Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
Mutat Res. 1989 Nov;224(3):365-8. doi: 10.1016/0165-1218(89)90181-x.
Male Fischer 344 rats were treated with the non-carcinogenic chemicals CAP and ZOIN. The spermatogenic cells were isolated at selected times post-exposure for assessment of chemically-induced DNA damage by quantitative autoradiography of unscheduled DNA synthesis (UDS). Neither chemical (750 mg/kg administered by gavage) induced UDS in pachytene spermatocytes isolated 12, 24 or 48 h after treatment.
