Raglan Greta B, Schmidt Louis A, Schulkin Jay
Department of PsychologyAmerican University, Washington, District of Columbia, USA
Department of PsychologyNeuroscience & Behavior, McMaster University, Hamilton, Ontario, Canada.
Endocr Connect. 2017 Feb;6(2):R1-R7. doi: 10.1530/EC-16-0100. Epub 2017 Jan 24.
The stress response has been linked to the expression of anxiety and depression, but the mechanisms for these connections are under continued consideration. The activation and expression of glucocorticoids and CRH are variable and may hold important clues to individual experiences of mood disorders. This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations. In addition, it focuses on ways in which extra-hypothalamic glucocorticoids and CRH, often overlooked, may play important roles in the presentation of clinical disorders.
应激反应与焦虑和抑郁的表达有关，但这些联系的机制仍在持续探讨中。糖皮质激素和促肾上腺皮质激素释放激素（CRH）的激活和表达是可变的，可能为情绪障碍的个体经历提供重要线索。本文探讨了糖皮质激素和CRH在焦虑症和抑郁症表现中的相互作用，以便更好地描述它们在每种临床表现中的不同作用。此外，本文还关注常常被忽视的下丘脑外糖皮质激素和CRH在临床疾病表现中可能发挥重要作用的方式。
