Roses A D
Division of Neurology, Duke University Medical Center, Durham, NC 27710.
Neurobiol Aging. 1989 Sep-Oct;10(5):427-9; discussion 446-8. doi: 10.1016/0197-4580(89)90083-3.
Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretation. The actual location of a genetic locus (or loci) for Alzheimer's disease in the human genome will not be influenced by this controversy; more data from exclusion mapping and the use of several methods of linkage analysis will answer current questions.
