Yan Yunmeng, Fu Guangzhen, Ye Yafei, Ming Liang
a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China.
b Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province , Zhengzhou , PR China.
Scand J Gastroenterol. 2017 May;52(5):499-504. doi: 10.1080/00365521.2016.1278458. Epub 2017 Jan 27.
In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC).
Exosomes are vesicles of endocytic origin ranging from 30 to 100 nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC.
In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes? potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC.
Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.
总结外泌体在胃癌侵袭和转移中的作用。
外泌体是内吞来源的囊泡，大小在30至100纳米之间；它们由脂质双层组成，包含DNA、mRNA、miRNA、环状RNA和多种蛋白质。最近，越来越多的证据表明外泌体在胃癌的肿瘤发生中起关键作用。
在本综述中，我们关注胃癌外泌体的最新发现，主要总结它们在胃癌侵袭和转移中的作用。然后，简要讨论了外泌体作为胃癌新型诊断和治疗生物标志物的潜在功能。最后，我们展望了外泌体在胃癌中的临床应用前景。
外泌体在胃癌的发生和转移中起着至关重要的作用。
