Balasubramanian T, Karthikeyan M, Muhammed Anees K P, Kadeeja C P, Jaseela K
a Department of Pharmacology , Al Shifa College of Pharmacy , Kerala , India.
J Diet Suppl. 2017 Jul 4;14(4):395-410. doi: 10.1080/19390211.2016.1265037. Epub 2017 Jan 27.
Amaranthus hybridus (Amaranthaceae) has been used as a folk medicine in southern parts of India for the treatment of diabetes.
This research evaluates the antidiabetic and antioxidant effects of Amaranthus hybridus ethanol leaf extract (AHELE) in streptozotocin-induced diabetic rats.
Blood glucose levels of diabetic rats were measured on days 1, 4, 7, and 15 after oral administration of AHELE at doses of 200 and 400 mg/kg for 14 days. The effects of extract were observed on serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, cholesterol, high- and low-density lipoprotein, antioxidant potential, and histopathological changes.
AHELE (200 and 400 mg/kg) caused a significant (p < 0.001) reduction in blood glucose levels on day 15 (152.2 and 181.2 mg/dL, respectively versus diabetic control 287.0 mg/dL). The extract also improved serum biochemical parameters associated with diabetes. A significant (p < 0.001) decrease in malondialdehyde protein (liver: 15.92, 12.29 nmol/mg, and kidney: 13.92, 10.29 nmol/mg vs. diabetic control 25.49, 24.49 nmol/mg), increase in superoxide dismutase protein (14.01; 17.47 IU/mg, and 25.01; 37.47 IU/mg vs. diabetic control 9.65; 15.65 IU/mg), catalase protein (35.80, 44.49, and 39.80, 49.69 nmol/min/mg vs. diabetic control 18.45, 20.85 nmol/min/mg) and reduced glutathione protein (44.77, 55.08 and 40.77, 51.08 μM/gm vs. diabetic control 29.81, 26.50 μM/gm) were observed.
The study reveals that treatment of diabetic rats with AHELE significantly reduced hyperglycemia-associated oxidative damage. This could provide a rationale for the use of the plant to treat diabetes in folk medicine.
杂交苋（苋科）在印度南部被用作民间药物治疗糖尿病。
本研究评估杂交苋乙醇叶提取物（AHELE）对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病和抗氧化作用。
给糖尿病大鼠口服剂量为200和400mg/kg的AHELE，持续14天，在第1、4、7和15天测量血糖水平。观察提取物对血清谷氨酸草酰乙酸转氨酶、血清谷氨酸丙酮酸转氨酶、血清碱性磷酸酶、胆固醇、高密度和低密度脂蛋白、抗氧化能力以及组织病理学变化的影响。
AHELE（200和400mg/kg）在第15天导致血糖水平显著降低（p<0.001）（分别为152.2和181.2mg/dL，而糖尿病对照组为287.0mg/dL）。该提取物还改善了与糖尿病相关的血清生化参数。观察到丙二醛蛋白显著降低（p<0.001）（肝脏：15.92、12.29nmol/mg，肾脏：13.92、10.29nmol/mg，而糖尿病对照组为25.49、24.49nmol/mg），超氧化物歧化酶蛋白增加（14.01；17.47IU/mg，以及25.01；37.47IU/mg，而糖尿病对照组为9.65；15.65IU/mg），过氧化氢酶蛋白（35.80、44.49，以及39.80、49.69nmol/min/mg，而糖尿病对照组为18.45、20.85nmol/min/mg）和还原型谷胱甘肽蛋白增加（44.77、55.08以及40.77、51.08μM/gm，而糖尿病对照组为29.81、26.50μM/gm）。
该研究表明，用AHELE治疗糖尿病大鼠可显著降低与高血糖相关的氧化损伤。这可为该植物在民间医学中用于治疗糖尿病提供理论依据。
