一般人群中休闲时间和职业体力活动及心肺适能与新发和复发性重度抑郁症、抑郁症状及新发焦虑症的关联

Associations of Leisure-Time and Occupational Physical Activity and Cardiorespiratory Fitness With Incident and Recurrent Major Depressive Disorder, Depressive Symptoms, and Incident Anxiety in a General Population.

作者信息

Baumeister Sebastian E, Leitzmann Michael F, Bahls Martin, Dörr Marcus, Schmid Daniela, Schomerus Georg, Appel Katja, Markus Marcello R P, Völzke Henry, Gläser Sven, Grabe Hans-Jörgen

机构信息

Department of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, D-93053 Regensburg, Germany.

Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

出版信息

J Clin Psychiatry. 2017 Jan;78(1):e41-e47. doi: 10.4088/JCP.15m10474.

DOI:10.4088/JCP.15m10474

PMID:28129498

Abstract

OBJECTIVE

Physical activity and cardiorespiratory fitness may help prevent depression and anxiety. Previous studies have been limited by error-prone measurements. We examined whether self-reported physical activity domains and peak exercise capacity (peakVO₂) are associated with incident and recurrent major depressive disorder (MDD), depressive symptoms, and anxiety disorders.

METHODS

This was a prospective population-based study of 1,080 adult men and women (25-83 years) with a median follow-up of 4.5 years and measures of physical activity during leisure time, sports, and work (Baecke questionnaire); a measure of depressive symptoms (Beck Depression Inventory II); symptom-limited cycle ergometer testing (peakVO₂, oxygen uptake at anaerobic threshold [VO₂@AT], maximum power output at peak exertion); and a structured psychiatric interview (Munich Composite International Diagnostic Interview). Baseline data were collected between 2002 and 2006, and follow-up data, between 2007 and 2010.

RESULTS

After adjustment for age, sex, education, smoking, alcohol consumption, and waist circumference, the relative risks for incident MDD per standard deviation (SD) increase in leisure-time physical activity, physical activity during sport, physical activity at work, peakVO₂, VO₂@AT, and maximum power output were 1.002 (95% confidence interval, 0.90 to 1.12), 1.02 (0.90 to 1.15), 0.94 (0.80 to 1.10), 0.71 (0.52 to 0.98), 0.83 (0.66 to 1.04), and 0.71 (0.52 to 0.96), respectively. PeakVO₂, VO₂@AT, and maximum power output were associated with recurrent MDD, depressive symptoms, and anxiety. PeakVO₂ was more strongly related to the co-occurrence of MDD and anxiety (adjusted odds ratio [OR] = 0.45 [0.24 to 0.84]) than depression or anxiety alone (OR = 0.71 [0.53 to 0.94]).

CONCLUSIONS

Greater cardiorespiratory fitness but not domain-specific physical activity was associated with a lower incidence of MDD and clinical anxiety.

摘要

目的

身体活动和心肺适能可能有助于预防抑郁和焦虑。既往研究受测量易出错的限制。我们研究了自我报告的身体活动领域和峰值运动能力（峰值摄氧量）是否与新发和复发性重度抑郁症（MDD）、抑郁症状及焦虑症相关。

方法

这是一项基于人群的前瞻性研究，纳入1080名成年男性和女性（25 - 83岁），中位随访时间为4.5年，测量了休闲时间、运动和工作期间的身体活动（贝克问卷）；抑郁症状测量（贝克抑郁量表第二版）；症状限制的蹬车运动测试（峰值摄氧量、无氧阈摄氧量、最大用力时的最大功率输出）；以及结构化精神科访谈（慕尼黑综合国际诊断访谈）。2002年至2006年收集基线数据，2007年至2010年收集随访数据。

结果

在调整年龄、性别、教育程度、吸烟、饮酒和腰围后，休闲时间身体活动、运动期间身体活动、工作期间身体活动、峰值摄氧量、无氧阈摄氧量和最大功率输出每增加一个标准差，新发MDD的相对风险分别为1.002（95%置信区间，0.90至1.12）、1.02（0.90至1.15）、0.94（0.80至1.10）、0.71（0.52至0.98）、0.83（0.66至1.04）和0.71（0.52至0.96）。峰值摄氧量、无氧阈摄氧量和最大功率输出与复发性MDD、抑郁症状及焦虑相关。峰值摄氧量与MDD和焦虑共病的相关性（调整后的优势比[OR]=0.45[0.24至0.84]）比单独的抑郁或焦虑更强（OR = 0.71[0.53至0.94]）。