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一只狗身上的皮肤混合瘤。

A cutaneous mixed tumor in a dog.

作者信息

Watanabe Ken-Ichi, Chambers James K, Uchida Kazuyuki, Nibe Kazumi, Ushio Nanako, Horiuchi Noriyuki, Kobayashi Yoshiyasu, Nakayama Hiroyuki

机构信息

Department of Veterinary Medicine, Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-0834, Japan.

出版信息

J Vet Med Sci. 2017 Mar 28;79(3):670-673. doi: 10.1292/jvms.16-0610. Epub 2017 Jan 28.

DOI:10.1292/jvms.16-0610
PMID:28132963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5383195/
Abstract

The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neoplastic cells in trichoblastic area were also positive for cytokeratin 15 and CD34. Neoplastic cells in apocrine glandular area were positive for pan-cytokeratin and cytokeratin 7, 18 and 19. Myoepithelial cell proliferation with osteocartilaginous metaplasia was observed in this area. Since neoplastic cells showed multiphenotypic differentiation for hair follicles and apocrine glands, the present case was diagnosed as a cutaneous mixed tumor.

摘要

对一只9岁的杂种雌性犬的非典型皮肤肿瘤进行了检查。该肿瘤边界清晰，组织学上由毛母质区、外毛根鞘区和顶泌腺区组成。毛母质区和外毛根鞘区的肿瘤细胞胞质内有PAS阳性颗粒，对泛细胞角蛋白、细胞角蛋白5/6、14和19以及p63呈阳性。毛母质区的肿瘤细胞对细胞角蛋白15和CD34也呈阳性。顶泌腺区的肿瘤细胞对泛细胞角蛋白以及细胞角蛋白7、18和19呈阳性。在该区域观察到伴有骨软骨化生的肌上皮细胞增殖。由于肿瘤细胞显示出毛囊和顶泌腺的多表型分化，本例被诊断为皮肤混合瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/57dc030766c6/jvms-79-670-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/894bde6547f1/jvms-79-670-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/5c93ac0ef42a/jvms-79-670-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/793fdc970a20/jvms-79-670-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/fcbfa01f4029/jvms-79-670-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/57dc030766c6/jvms-79-670-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/894bde6547f1/jvms-79-670-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/d15efe90bf74/jvms-79-670-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/cf426f78c62a/jvms-79-670-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/3e2b186cb596/jvms-79-670-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/5c93ac0ef42a/jvms-79-670-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/793fdc970a20/jvms-79-670-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/fcbfa01f4029/jvms-79-670-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c69e/5383195/57dc030766c6/jvms-79-670-g008.jpg

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本文引用的文献

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Trichoblastoma with abundant plump stromal cells in a dog.一只患有富含丰满基质细胞的毛母细胞瘤的犬
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