人诱导多能干细胞在植入皮质下缺血性中风模型前的神经分化成熟状态的影响
Effects of neural differentiation maturity status of human induced pluripotent stem cells prior to grafting in a subcortical ischemic stroke model.
作者信息
Jensen Matthew B, Jager Lindsey D, Cohen Laura K, Kwok Susanna S, Kwon Jin M, Hall Crystal A, Heilingoetter Cassandra
机构信息
University of Wisconsin Department of Neurology.
出版信息
Neurol Psychiatry Brain Res. 2016 Dec;22(3-4):178-182. doi: 10.1016/j.npbr.2016.02.001. Epub 2016 Apr 6.
Abstract
Neural cell grafting is a promising therapy for stroke, but the optimal differentiation status of the cells prior to grafting is unclear. We grafted cells at different maturity stages (days 28, 42, or 56 of in vitro neural differentiation) into the brains of eight-week-old rats one week after subcortical ischemic stroke, and assessed motor and sensory behavioral recovery over one month. We did not find a difference between the grafted or control groups on behavioral recovery, or on brain tissue outcomes including infarct size, microgliosis, or astrocytosis. Further research is needed into mechanisms of benefit of neural cell grafting for stroke.
摘要
神经细胞移植是一种很有前景的中风治疗方法，但移植前细胞的最佳分化状态尚不清楚。我们在皮质下缺血性中风一周后，将处于不同成熟阶段（体外神经分化第28、42或56天）的细胞移植到八周龄大鼠的大脑中，并在一个月内评估运动和感觉行为恢复情况。我们没有发现移植组和对照组在行为恢复或脑组织结果（包括梗死面积、小胶质细胞增生或星形细胞增生）方面存在差异。需要进一步研究神经细胞移植对中风有益的机制。
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