Bejder J, Andersen A B, Goetze J P, Aachmann-Andersen N J, Nordsborg N B
Department of Nutrition, Exercise and Sports (NEXS), Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Scand J Med Sci Sports. 2017 Dec;27(12):1605-1615. doi: 10.1111/sms.12825. Epub 2017 Jan 30.
The time course of plasma volume (PV) reduction following an increased training load period is unknown and was investigated. The accompanying fluctuations in [Hb] and OFF-hr score were analyzed in the Athlete Biological Passport. Further, whether fluctuations in plasma albumin, soluble transferrin receptors (sTfR), and pro-atrial natriuretic peptide (proANP) concentrations correlate with PV fluctuations was investigated. Eleven high-level competitive cyclists were investigated for 3 weeks. After initial measurements in week 1, training load was increased ~250% in week 2 followed by a reversion to baseline training load in week 3. PV and hematological variables were determined frequently during all weeks. The higher training load in week 2 increased (P<.001) PV 10%, while [Hb] and OFF-hr score decreased ~6% (P<.01) and ~16% (P<.001), respectively. PV and [Hb] returned to baseline within 2 and 4 days after week 2, respectively, while OFF-hr score remained reduced for 6 days. Further, one and three atypical blood profiles of the ABP occurred during weeks 2 and 3, respectively. Individual changes in albumin, sTfR, and proANP only correlated weakly (R <.20) with PV fluctuations. In conclusion, PV and [Hb] fluctuations caused by an elevated training load period were reverted within 2 and 4 days after returning to baseline training load, respectively, while OFF-hr remained altered for 6 days. Furthermore, some atypical blood profiles were induced during and subsequent to the increased training load, demonstrating the importance of knowledge on naturally occurring hematological fluctuations. Finally, concentrations of albumin, sTfR, and proANP could not explain PV fluctuations.
训练负荷增加期后血浆容量（PV）减少的时间进程尚不清楚，因此对此进行了研究。在运动员生物护照中分析了伴随的血红蛋白（[Hb]）和非训练时间得分的波动情况。此外，还研究了血浆白蛋白、可溶性转铁蛋白受体（sTfR）和心房利钠肽原（proANP）浓度的波动与PV波动是否相关。对11名高水平自行车运动员进行了为期3周的研究。在第1周进行初始测量后，第2周训练负荷增加了约250%，随后在第3周恢复到基线训练负荷。在所有周内频繁测定PV和血液学变量。第2周较高的训练负荷使PV增加了10%（P<0.001），而[Hb]和非训练时间得分分别下降了约6%（P<0.01）和16%（P<0.001）。PV和[Hb]分别在第2周后的2天和4天内恢复到基线水平，而非训练时间得分在6天内仍保持降低。此外，在第2周和第3周分别出现了1例和3例运动员生物护照的非典型血液学图谱。白蛋白、sTfR和proANP的个体变化与PV波动仅呈弱相关（R<0.20）。总之，训练负荷增加期引起的PV和[Hb]波动在恢复到基线训练负荷后的2天和4天内分别恢复，而非训练时间得分在6天内仍保持改变。此外，在训练负荷增加期间及之后出现了一些非典型血液学图谱，这表明了解自然发生的血液学波动的重要性。最后，白蛋白、sTfR和proANP的浓度无法解释PV波动。
