Fong Alex, Chau Cindy T, Quant Cara, Duffy Jennifer, Pan Deyu, Ogunyemi Dotun A
a Department of Obstetrics and Gynecology , Memorial Care Center for Women at Miller Children's Hospital Long Beach , Long Beach , CA , USA.
b Department of Obstetrics and Gynecology , University of California , Irvine, Orange , CA, USA.
J Matern Fetal Neonatal Med. 2018 Feb;31(3):382-387. doi: 10.1080/14767058.2017.1286314. Epub 2017 Apr 10.
We sought to describe the prevalence, sociodemographic features, and antenatal/peripartum outcomes of multiple sclerosis (MS) in pregnancy.
A retrospective cohort study was performed using deliveries in California from 2001 to 2009. Cases of MS as well as other morbidities were identified via ICD-9-CM code. Logistic regression was performed to adjust for potential confounders.
About 1185 out of 4,424,049 deliveries were complicated by MS. MS prevalence increased with maternal age, with Caucasians comprising a higher proportion of MS subjects. MS subjects were older and more likely to have private insurance. Women with MS were more likely to have preexisting medical conditions such as asthma, chronic hypertension, thyroid disease, or cardiac disease. However, no significant antepartum and peripartum morbidities were found to be increased in patients with MS. Urinary tract infection, cesarean delivery, and induction of labor were slightly increased in MS patients.
MS is a rare condition which is more likely to affect older Caucasian women of higher socioeconomic status and is associated with several preexisting medical conditions. MS, however, does not appear to pose significant increases in adverse pregnancy outcome. This suggests that pregnant patients with MS may likely experience an uneventful pregnancy.
我们试图描述妊娠期间多发性硬化症（MS）的患病率、社会人口学特征及产前/围产期结局。
采用回顾性队列研究，纳入2001年至2009年在加利福尼亚州的分娩病例。通过国际疾病分类第九版临床修订本（ICD - 9 - CM）编码确定MS病例以及其他疾病。进行逻辑回归以调整潜在混杂因素。
在4424049例分娩中，约1185例合并MS。MS患病率随产妇年龄增加而升高，白人在MS患者中所占比例更高。MS患者年龄较大，更有可能拥有私人保险。患有MS的女性更有可能患有如哮喘、慢性高血压、甲状腺疾病或心脏病等既往疾病。然而，未发现MS患者的产前和围产期发病率显著增加。MS患者的尿路感染、剖宫产和引产率略有升高。
MS是一种罕见疾病，更易影响社会经济地位较高的老年白人女性，且与多种既往疾病相关。然而，MS似乎并未导致不良妊娠结局显著增加。这表明患有MS的孕妇可能经历平稳的妊娠过程。
