来自肾茶水提取物的具有神经保护作用的酚酸衍生物。
Phenolic acid derivatives with neuroprotective effect from the aqueous extract of Clerodendranthus spicatus.
作者信息
Zhou Hai-Chun, Yang Liu, Guo Rui-Zhu, Li Ji
机构信息
a Acupuncture and Moxibustion Department , The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine , Harbin 150009 , China.
b Acupuncture and Moxibustion Department , Harbin Medical University , Harbin 150001 , China.
出版信息
J Asian Nat Prod Res. 2017 Oct;19(10):974-980. doi: 10.1080/10286020.2016.1277707. Epub 2017 Jan 31.
Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures were elucidated on the basis of 1D and 2D NMR, MS, and CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in the previously isolated phenolic acid derivatives. The two compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells, and the result showed that compounds 1 and 2 displayed moderate neuroprotective activity with the IC values of 17.4 and 21.3 μM, respectively.
从肾茶全株中分离得到两种新的酚酸类化合物毛药忍冬素C（1）和D（2）。通过一维和二维核磁共振、质谱以及圆二色光谱分析确定了它们的结构。化合物1具有一个不寻常的双环[2.2.2]辛烷部分，这在先前分离得到的酚酸衍生物中较为罕见。对这两种化合物进行了体外测试，考察其对6-羟基多巴胺诱导的SH-SY5Y细胞死亡的神经保护活性，结果表明化合物1和2表现出中等程度的神经保护活性，IC50值分别为17.4和21.3 μM。
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