精神分裂症患者大脑的结构与功能分离模式
Brain structural and functional dissociated patterns in schizophrenia.
作者信息
Zhuo Chuanjun, Zhu Jiajia, Wang Chunli, Qu Hongru, Ma Xiaolei, Tian Hongjun, Liu Mei, Qin Wen
机构信息
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
Department of Psychiatry Functional Neuroimaging Laboratory, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin, China.
出版信息
BMC Psychiatry. 2017 Jan 31;17(1):45. doi: 10.1186/s12888-017-1194-5.
BACKGROUND
Although previous studies found that aberrations in gray matter volume (GMV) and global functional connectivity density (gFCD) are important characteristics of schizophrenia, to the best of our knowledge no study to date has investigated the associations between the spatial distribution patterns of GMV and gFCD alterations. We investigated pattern changes in gFCD and GMV among patients with schizophrenia and their associated spatial distributions.
METHODS
Ninety-five patients with schizophrenia and 93 matched healthy controls underwent structural and resting-state functional MRI scanning to assess gFCD and GMV.
RESULTS
We found that gFCD increased in the subcortical regions (caudate, pallidum, putamen, and thalami) and limbic system (left hippocampus and parahippocampus), and decreased in the posterior parieto-occipito-temporal cortices (postcentral gyri, occipital cortex, temporo-occipital conjunction, and inferior parietal lobule), in patients with schizophrenia. By contrast, we found decreased GMV in brain regions including the frontal, parietal, temporal, occipital, cingulate cortices, and the insular, striatum, thalamus in these patients. Increased gFCD primarily occurred in subcortical regions including the basal ganglia and some regions of the limbic system. Decreased gFCD appeared primarily in the cortical regions. There were no statistically significant correlations between changes in gFCD and GMV, and their spatial distribution patterns, in different regions.
CONCLUSIONS
Our findings indicate that gFCD and GMV are both perturbed in multiple brain regions in schizophrenia. gFCD and GMV consistently decreased in the cortical regions, with the exception of the Supplementary Motor Area (SMA). However, in the sub-cortical regions, the alterations of gFCD and GMV showed the opposite pattern, with increased gFCD and decreased GMV simultaneously observed in these regions. Overall, our findings suggest that structural and functional alterations appear to contribute independently to the neurobiology of schizophrenia.
背景
尽管先前的研究发现灰质体积（GMV）异常和全脑功能连接密度（gFCD）是精神分裂症的重要特征，但据我们所知，迄今为止尚无研究探讨GMV和gFCD改变的空间分布模式之间的关联。我们研究了精神分裂症患者中gFCD和GMV的模式变化及其相关的空间分布。
方法
95例精神分裂症患者和93例匹配的健康对照者接受了结构和静息态功能MRI扫描，以评估gFCD和GMV。
结果
我们发现，精神分裂症患者的皮质下区域（尾状核、苍白球、壳核和丘脑）和边缘系统（左侧海马和海马旁回）的gFCD增加，而后顶枕颞叶皮质（中央后回、枕叶皮质、颞枕联合和顶下小叶）的gFCD降低。相比之下，我们发现这些患者的额叶、顶叶、颞叶、枕叶、扣带回皮质以及岛叶、纹状体、丘脑等脑区的GMV降低。gFCD增加主要发生在包括基底神经节和边缘系统一些区域在内的皮质下区域。gFCD降低主要出现在皮质区域。不同区域gFCD和GMV的变化及其空间分布模式之间无统计学显著相关性。
结论
我们的研究结果表明，精神分裂症患者多个脑区的gFCD和GMV均受到干扰。除辅助运动区（SMA）外，皮质区域的gFCD和GMV持续降低。然而，在皮质下区域，gFCD和GMV的改变呈现相反模式，这些区域同时观察到gFCD增加和GMV降低。总体而言，我们的研究结果表明，结构和功能改变似乎对精神分裂症的神经生物学有独立贡献。
Zotero 插件