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Effectiveness of hepatitis B rapid tests toward linkage-to-care: results of a randomized, multicenter study.乙肝快速检测在关联到治疗方面的有效性：一项随机多中心研究的结果
Eur J Gastroenterol Hepatol. 2016 Jun;28(6):633-9. doi: 10.1097/MEG.0000000000000620.
2
Update on hepatitis B and C virus diagnosis.乙型和丙型肝炎病毒诊断的最新进展。
World J Virol. 2015 Nov 12;4(4):323-42. doi: 10.5501/wjv.v4.i4.323.
3
A Simple and Rapid Test-card Method to Detect Hepatitis B Surface Antigen and Antibody: Potential Application in Young Children and Infants.一种检测乙型肝炎表面抗原和抗体的简单快速检测卡方法：在幼儿和婴儿中的潜在应用
Pediatr Neonatol. 2016 Jun;57(3):219-24. doi: 10.1016/j.pedneo.2015.07.003. Epub 2015 Oct 23.
4
Low prevalence of hepatitis B and C virus markers among children and adolescents.儿童和青少年中乙肝和丙肝病毒标志物的低流行率。
Biomed Res Int. 2014;2014:324638. doi: 10.1155/2014/324638. Epub 2014 Jul 1.
5
Knowledge and prevalence of viral hepatitis among beauticians.美容师对病毒性肝炎的认知和流行情况。
J Med Virol. 2014 Sep;86(9):1515-21. doi: 10.1002/jmv.23993. Epub 2014 Jun 10.
6
Evaluation of commercialized rapid diagnostic testing for some Hepatitis B biomarkers in an area of intermediate endemicity.商业化快速诊断检测在中度流行地区一些乙型肝炎生物标志物的评估。
J Virol Methods. 2013 Dec;194(1-2):190-3. doi: 10.1016/j.jviromet.2013.08.026. Epub 2013 Sep 1.
7
Medical virology of hepatitis B: how it began and where we are now.乙型肝炎的医学病毒学：它的起源和我们现在所处的位置。
Virol J. 2013 Jul 20;10:239. doi: 10.1186/1743-422X-10-239.
8
Key drug use, health and socio-economic characteristics of young crack users in two Brazilian cities.年轻可卡因吸食者的主要用药情况、健康状况和社会经济特征：来自两个巴西城市的报告
Int J Drug Policy. 2013 Sep;24(5):432-8. doi: 10.1016/j.drugpo.2013.03.012. Epub 2013 Apr 28.
9
Performance of rapid tests for detection of HBsAg and anti-HBsAb in a large cohort, France.在一个大型队列中，快速检测 HBsAg 和抗-HBsAb 的性能，法国。
J Hepatol. 2013 Mar;58(3):473-8. doi: 10.1016/j.jhep.2012.11.016. Epub 2012 Nov 23.
10
Rapid point-of-care first-line screening tests for hepatitis B infection: a meta-analysis of diagnostic accuracy (1980-2010).快速床旁一线筛查乙型肝炎感染的检测方法：诊断准确性的荟萃分析（1980-2010 年）。
Am J Gastroenterol. 2012 Sep;107(9):1306-13. doi: 10.1038/ajg.2012.141. Epub 2012 May 29.

用于检测乙型肝炎病毒抗体的快速检测方法灵敏度欠佳：对现场研究的影响。

Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies.

作者信息

Cruz Helena Medina, Scalioni Leticia de Paula, Paula Vanessa Salete de, Miguel Juliana Custódio, Ó Kycia Maria Rodrigues do, Milagres Flavio Augusto Pádua, Cruz Marcelo Santos, Bastos Francisco Inácio, Flores Priscila Pollo, Leal Erotildes, Motta-Castro Ana Rita Coimbra, Lewis-Ximenez Lia Laura, Lampe Elisabeth, Villar Livia Melo

机构信息

Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hepatites Virais, Rio de Janeiro, RJ, Brasil.

Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Desenvolvimento Tecnológico em Virologia, Rio de Janeiro, RJ, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2017 Mar;112(3):209-213. doi: 10.1590/0074-02760160394. Epub 2017 Jan 30.

DOI:10.1590/0074-02760160394
PMID:28146158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5319371/
Abstract

Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.

摘要

快速检测（RTs）可作为常规诊断乙型肝炎病毒（HBV）的替代方法。本研究旨在评估在巴西不同环境下针对乙型肝炎表面抗原（HBsAg）的抗体（抗-HBs）和针对乙型肝炎e抗原（HBeAg）的抗体（抗-HBe）快速检测。纳入了以下三组：第一组（GI）：病毒性肝炎门诊服务；第二组（GII）：资源匮乏地区；第三组（GIII）：吸毒者和美容师。对Imuno-rápido anti-HBsAg™和Imuno-rápido anti-HBeAg™快速检测进行了评估，结果显示在所有组中特异性均大于95%。GI组、GII组和GIII组中抗-HBs的敏感性值分别为50.38%、51.05%和46.73%，抗-HBe的敏感性值分别为76.99%、10.34%和11.76%。这些检测方法敏感性低、特异性高，表明它们可用于HBV流行地区的筛查。