Morrison Thomas E, Diamond Michael S
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
J Virol. 2017 Mar 29;91(8). doi: 10.1128/JVI.00009-17. Print 2017 Apr 15.
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barré syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Here, we review the recent advances in and utility and limitations of newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis.
寨卡病毒（ZIKV）是一种新出现的经蚊子传播的黄病毒，目前已在多个大洲引发疫情，影响数百万人。由于其一些不同寻常的流行病学和临床特征，该病毒受到了全球关注，这些特征包括在男性生殖道中的持续感染和性传播、孕期穿过胎盘感染发育中的胎儿并导致先天性畸形的能力，以及与成人吉兰-巴雷综合征的关联。过去一年，全球科学界付出了巨大努力来了解寨卡病毒的生物学特性，并开发发病机制模型以快速测试可能的应对措施。在此，我们综述了新开发的寨卡病毒感染和发病机制小鼠及非人灵长类动物模型的最新进展、效用及局限性。
