Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul 136-705, Korea.
Immunol Invest. 2013;42(6):455-69. doi: 10.3109/08820139.2013.804084.
The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA).
Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA.
A total of 12 comparative studies were included in this meta-analysis. Meta-analysis of the IL-4 -590 C/T polymorphism showed an association in all study subjects and Europeans (OR for the TT genotype = 2.280, 95% CI = 1.315-3.952, p = 0.003; OR = 2.139, 95% CI = 1.089-4.199, p = 0.027). However, meta-analysis showed no association between RA and the IL-4R 1902 G allele in all study subjects and Europeans. Meta-analysis showed no association between RA and the IL-18 -607 C allele (OR = 1.159, 95% CI = 0.967-1.387, p = 0.110). Meta-analysis of the IL-18 -137 G/C polymorphism revealed no association between RA and the IL-18 -137 G/C polymorphism.
This meta-analysis demonstrates that the IL-4 -590 T/C polymorphism is associated with susceptibility to RA in Europeans, but the IL-4R + 1902 G/A, IL-18 -607 C/A and -137 G/C polymorphisms are not associated with RA.
本研究旨在确定功能性白细胞介素-4（IL-4）-590C/T、IL-4 受体（IL-4R）1902G/A、IL-18-607C/A 和-137G/C 多态性是否与类风湿关节炎（RA）易感性相关。
对这些 IL-4、IL-4R 和 IL-18 多态性与 RA 之间的关联进行了荟萃分析。
共有 12 项比较研究纳入本荟萃分析。IL-4-590C/T 多态性的荟萃分析显示，在所有研究对象和欧洲人中均存在相关性（TT 基因型的 OR=2.280，95%CI=1.315-3.952，p=0.003；OR=2.139，95%CI=1.089-4.199，p=0.027）。然而，在所有研究对象和欧洲人中，IL-4R1902G 等位基因与 RA 之间的关联无统计学意义。IL-18-607C 等位基因与 RA 之间的关联无统计学意义（OR=1.159，95%CI=0.967-1.387，p=0.110）。IL-18-137G/C 多态性与 RA 之间的关联无统计学意义。
本荟萃分析表明，IL-4-590T/C 多态性与欧洲人 RA 易感性相关，而 IL-4R+1902G/A、IL-18-607C/A 和-137G/C 多态性与 RA 无关。
