2015年伊朗呼吸道感染患者中人类冠状病毒（229E）的证据：首例报告。
Evidence of human coroanvirus (229E), in patients with respiratory infection, Iran, 2015: the first report.
作者信息
Madhi Ali, Ghalyanchilangeroudi Arash, Soleimani Mohammad
机构信息
Department of Microbiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
出版信息
Iran J Microbiol. 2016 Oct;8(5):316-320.
BACKGROUND AND OBJECTIVES
Human coronaviruses (HCoVs) are one of the main causes of upper respiratory tract infections in humans. While more often responsible for mild illness, they have been associated with illnesses that require hospitalization.
MATERIALS AND METHODS
270 Samples from patients hospitalized with the respiratory infection during the autumn season of 2015 were evaluated for the presence of four HCoVs (OC43, 229E, HUK1, and NL63) using an optimized SYBR green RT-PCR assay.
RESULTS
Fifteen HCoV-229E positive samples were identified (5.5 % positive). 85% of positive samples were male with the range of age between 12- 75 years old.
CONCLUSION
It is the first comprehensive study on determination of the role of human coronaviruses in respiratory infections in Iran. Our data provide a novel insight into the epidemiology of HCoVs in Iran. Further studies are needed and should include the isolation and molecular characterization of HCoVs in Iran.
背景与目的
人类冠状病毒（HCoVs）是人类上呼吸道感染的主要病因之一。虽然它们更多时候引发轻症疾病，但也与需要住院治疗的疾病有关。
材料与方法
采用优化的SYBR Green RT-PCR检测法，对2015年秋季因呼吸道感染住院的患者的270份样本进行检测，以确定四种人类冠状病毒（OC43、229E、HUK1和NL63）的存在情况。
结果
鉴定出15份HCoV-229E阳性样本（阳性率为5.5%）。85%的阳性样本为男性，年龄在12至75岁之间。
结论
这是伊朗首次关于确定人类冠状病毒在呼吸道感染中作用的综合研究。我们的数据为伊朗HCoVs的流行病学提供了新的见解。还需要进一步的研究，应包括伊朗HCoVs的分离和分子特征分析。
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