通用蛋白质知识库
UniProt Protein Knowledgebase.
作者信息
Pundir Sangya, Martin Maria J, O'Donovan Claire
机构信息
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
出版信息
Methods Mol Biol. 2017;1558:41-55. doi: 10.1007/978-1-4939-6783-4_2.
Abstract
The Universal Protein Resource (UniProt) is a freely available comprehensive resource for protein sequence and annotation data. UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as expert curation, software development, and support.This chapter introduces the functionality and data provided by UniProt. It describes example use cases for which you might come to UniProt and the methods to help you achieve your goals.
摘要
通用蛋白质资源（UniProt）是一个免费提供的蛋白质序列和注释数据的综合资源库。UniProt是欧洲生物信息学研究所（EMBL-EBI）、瑞士生物信息学研究所（SIB）和蛋白质信息资源（PIR）之间的合作项目。这三个机构共有100多人参与其中，从事不同的工作，如专家管理、软件开发和技术支持。本章介绍了UniProt提供的功能和数据。它描述了你可能会用到UniProt的示例用例以及帮助你实现目标的方法。
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本文引用的文献
1
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Curr Protoc Bioinformatics. 2017 Sep 13;59:3.4.1-3.4.24. doi: 10.1002/cpbi.34.
2
UniProt: a hub for protein information.通用蛋白质数据库（UniProt）：蛋白质信息中心。
Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12. doi: 10.1093/nar/gku989. Epub 2014 Oct 27.
3
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega.使用 Clustal Omega 快速、可扩展地生成高质量蛋白质多重序列比对。
Mol Syst Biol. 2011 Oct 11;7:539. doi: 10.1038/msb.2011.75.
4
A comprehensive protein-centric ID mapping service for molecular data integration.综合性蛋白质中心 ID 映射服务，用于分子数据整合。
Bioinformatics. 2011 Apr 15;27(8):1190-1. doi: 10.1093/bioinformatics/btr101.
5
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Database (Oxford). 2011 Mar 29;2011:bar009. doi: 10.1093/database/bar009. Print 2011.
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