Kraal Kathelijne, Blom Thomas, van Noesel Max, Kremer Leontien, Caron Huib, Tytgat Godelieve, van der Pal Heleen
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26451. Epub 2017 Feb 2.
We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.
我们进行了一项系统综述，以确定伴有椎管内扩展的神经母细胞瘤患者的长期健康问题和最佳治疗策略。在685项已确定的研究中，本综述纳入了28项。长期健康问题的负担很重；中位50%的患者存在神经运动功能障碍，34%存在括约肌功能障碍，30%存在脊柱畸形。目前可用的文献作为伴有椎管内扩展的神经母细胞瘤治疗指南仍不理想。需要更多设计良好的前瞻性研究来确定最佳治疗策略。
