三价灭活疫苗（血清型4、5和12）与市售疫苗对仔猪猪传染性胸膜肺炎的疗效分析。
Analysis of efficacy obtained with a trivalent inactivated serovars 4, 5, and 12 vaccine and commercial vaccines against Glässer's disease in piglets.
作者信息
Zhao Zhanqin, Liu Huisheng, Xue Yun, Chen Kunpeng, Liu Zhijun, Xue Qiao, Wang Chen
机构信息
Laboratory of Veterinary Microbiology, College of Animal Science and Technology (Zhao, Liu, Chen, Q. Xue, Wang); Laboratory of Medical Engineering, College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China (Y. Xue).
出版信息
Can J Vet Res. 2017 Jan;81(1):22-27.
The objective of this study was to assess the efficacy of a trivalent inactivated serovars 4, 5, and 12 vaccine with polymeric adjuvant gel (GEL) and commercial vaccines against Glässer's disease in piglets. Commercial vaccines containing inactivated serovars 4 and 5 (China), inactivated serovars 1 and 6 (Spain), and inactivated serovar 5 (USA) were also evaluated. Our results demonstrated that the trivalent inactivated serovars 4, 5, and 12 vaccine with GEL adjuvant can provide better protection against the 3 most common pathogenic serovars circulating in China than other commercial vaccines tested. Our findings also indicated that inactivated serovars 1 and 6 vaccine cross-protects piglets against serovars 4 and 5; inactivated serovar 5 vaccine cross-protects piglets against serovar 4 challenge; but none of the commercial vaccines tested in this study protected piglets against serovar 12. Our results provide a basis for further identification of common protective antigens that can induce cross-protection against heterogeneous serovars.
本研究的目的是评估一种含有聚合佐剂凝胶（GEL）的三价灭活血清型4、5和12疫苗以及商业疫苗对仔猪猪传染性胸膜肺炎的疗效。还评估了含有灭活血清型4和5（中国）、灭活血清型1和6（西班牙）以及灭活血清型5（美国）的商业疫苗。我们的结果表明，与其他受试商业疫苗相比，含GEL佐剂的三价灭活血清型4、5和12疫苗能为中国流行的3种最常见致病血清型提供更好的保护。我们的研究结果还表明，灭活血清型1和6疫苗可使仔猪对血清型4和5产生交叉保护；灭活血清型5疫苗可使仔猪对血清型4的攻击产生交叉保护；但本研究中测试的商业疫苗均不能保护仔猪抵抗血清型12。我们的结果为进一步鉴定可诱导对异源血清型产生交叉保护的共同保护性抗原提供了依据。
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