Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
Exp Dermatol. 2017 Oct;26(10):952-954. doi: 10.1111/exd.13308. Epub 2017 Apr 27.
The stress-related neurohormones including glucocorticoids (GCs) are secreted by hair follicles (HFs), and GCs suppress murine hair growth in vivo. In this study, we found that dexamethasone (Dex), a synthetic GC, increased the expression of dickkopf-1 (DKK1), a known catagen inducer, in dermal papilla (DP) cells, but not in follicular keratinocytes. The neutralizing DKK1 antibody significantly attenuated the Dex-induced inhibition of human hair shaft elongation. In addition, the neutralizing Dkk1 antibody delayed Dex-induced catagen in mice. Collectively, our data strongly suggest that stress-related neurohormones cause DP cells to secrete DKK1, thereby leading to stress-associated disturbances in hair growth.
压力相关的神经激素包括糖皮质激素（GCs），由毛囊（HFs）分泌，GCs 在体内抑制小鼠毛发生长。在这项研究中，我们发现地塞米松（Dex），一种合成的 GC，增加了真皮乳头（DP）细胞中已知的休止期诱导物 dickkopf-1（DKK1）的表达，但不在毛囊角质形成细胞中。中和 DKK1 抗体显著减弱了 Dex 诱导的人毛干伸长抑制。此外，中和 Dkk1 抗体延迟了 Dex 诱导的小鼠休止期。总的来说，我们的数据强烈表明，压力相关的神经激素导致 DP 细胞分泌 DKK1，从而导致与压力相关的毛发生长紊乱。
