Vittorio Orazio, Curcio Manuela, Cojoc Monica, Goya Gerardo F, Hampel Silke, Iemma Francesca, Dubrovska Anna, Cirillo Giuseppe
a UNSW Australia, Children's Cancer Institute, Lowy Cancer Research Center and ARC Center of Excellence in Convergent Bio-Nano Science and Technology, Australian Center for NanoMedicine , Sydney , NSW , Australia.
b Department of Pharmacy Health and Nutritional Science , University of Calabria, Arcavacata di Rende , Italy.
Drug Deliv. 2017 Nov;24(1):162-180. doi: 10.1080/10717544.2016.1236846.
Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.
纳米技术可为提高多酚的治疗效果提供不同的解决方案。多酚是一类天然产物，因其在包括癌症在内的多种疾病治疗中的潜在适用性而被广泛研究。尽管多酚具有有趣的抗癌特性，但它们稳定性低且药代动力学性质不佳，因此在制定治疗方案时需要合适的载体。在本综述中，我们概述了基于聚合物材料的不同策略，旨在突出每种方法的优缺点，并为该领域的研究人员提供一个思路平台。
