Whitehouse W, Quimby J, Wan S, Monaghan K, Robbins R, Trepanier L A
Department of Medical Sciences, University of Wisconsin-Madison, Madison, WI.
College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
J Vet Intern Med. 2017 Mar;31(2):449-456. doi: 10.1111/jvim.14634. Epub 2017 Feb 4.
F -isoprostanes, a biomarker of oxidant injury, increase with advancing chronic kidney disease (CKD) in humans. In cats, the relationship between CKD and oxidative stress is poorly understood.
To determine whether cats with advancing CKD have increasing urinary F -isoprostanes.
Control cats without evidence of CKD (≥6 years old; n = 11), and cats with IRIS stage 1 (n = 8), 2 (n = 38), 3 (n = 21), and 4 (n = 10) CKD.
This was a prospective observational study. Urinary F -isoprostanes (specifically free 15-F -isoprostanes) normalized to urine creatinine (IsoPs) were compared among groups and tested for correlations with blood pressure, proteinuria, serum creatinine concentration, and urine specific gravity. The IsoPs also were compared between cats with and without hypertension or proteinuria, and in cats fed predominantly standard versus renal diets.
Urinary IsoPs were increased, but not significantly, in cats with stage 1 CKD (median 263 pg/mg creatinine; range, 211-380) compared to controls (182 pg/mg; range, 80-348) and decreased significantly from stage 1 through advancing CKD (stage 2, 144 pg/mg; range, 49-608; stage 3, 102 pg/mg; range, 25-158; stage 4, 67 pg/mg; range, 26-117; P < .01). Urinary IsoPs were inversely correlated with serum creatinine (r = -0.66, P < .0001).
Urinary IsoPs are significantly higher in early CKD (stage 1) compared to cats with more advanced CKD. Additional studies are warranted to characterize oxidative stress in cats with stage 1 CKD and determine whether early antioxidant treatments have a protective effect on CKD progression.
F-异前列腺素是氧化损伤的生物标志物，在人类中随着慢性肾脏病（CKD）的进展而增加。在猫中，CKD与氧化应激之间的关系尚不清楚。
确定患有进展性CKD的猫尿F-异前列腺素是否增加。
无CKD证据的对照猫（≥6岁；n = 11），以及国际肾脏病研究学会（IRIS）1期（n = 8）、2期（n = 38）、3期（n = 21）和4期（n = 10）CKD的猫。
这是一项前瞻性观察性研究。将尿F-异前列腺素（具体为游离15-F-异前列腺素）标准化为尿肌酐（IsoPs）后在各组间进行比较，并测试其与血压、蛋白尿、血清肌酐浓度和尿比重的相关性。还比较了有和没有高血压或蛋白尿的猫之间的IsoPs，以及主要喂食标准饮食与肾脏饮食的猫之间的IsoPs。
与对照组（182 pg/mg；范围80 - 348）相比，1期CKD猫的尿IsoPs有所增加，但无显著差异（中位数263 pg/mg肌酐；范围211 - 380），并且从1期到进展性CKD显著下降（2期，144 pg/mg；范围49 - 608；3期，102 pg/mg；范围25 - 158；4期，67 pg/mg；范围26 - 117；P <.01）。尿IsoPs与血清肌酐呈负相关（r = -0.66，P <.0001）。
与更晚期CKD的猫相比，早期CKD（1期）猫的尿IsoPs显著更高。有必要进行更多研究来描述1期CKD猫的氧化应激特征，并确定早期抗氧化治疗是否对CKD进展有保护作用。
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