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中期纺锤体组装

Metaphase Spindle Assembly.

作者信息

Kapoor Tarun M

机构信息

Laboratory of Chemistry and Cell Biology, the Rockefeller University, New York, NY 10065, USA.

出版信息

Biology (Basel). 2017 Feb 3;6(1):8. doi: 10.3390/biology6010008.

DOI:10.3390/biology6010008
PMID:28165376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5372001/
Abstract

A microtubule-based bipolar spindle is required for error-free chromosome segregation during cell division. In this review I discuss the molecular mechanisms required for the assembly of this dynamic micrometer-scale structure in animal cells.

摘要

在细胞分裂过程中,基于微管的双极纺锤体对于无差错的染色体分离是必需的。在这篇综述中,我将讨论动物细胞中这种动态微米级结构组装所需的分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f38/5372001/b0aeb50ceb91/biology-06-00008-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f38/5372001/b0aeb50ceb91/biology-06-00008-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f38/5372001/b0aeb50ceb91/biology-06-00008-g004.jpg

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本文引用的文献

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Kinesin-5 inhibitor resistance is driven by kinesin-12.驱动蛋白-5抑制剂耐药性由驱动蛋白-12介导。
J Cell Biol. 2016 Apr 25;213(2):213-27. doi: 10.1083/jcb.201507036. Epub 2016 Apr 18.
3
Review: Structure and mechanism of the dynein motor ATPase.综述:动力蛋白马达ATP酶的结构与机制
多种微管结合重复序列在纺锤体内不同位置调节TPX2活性。
J Cell Biol. 2025 Mar 3;224(3). doi: 10.1083/jcb.202404025. Epub 2025 Jan 16.
4
Unveiling inter-embryo variability in spindle length over time: Towards quantitative phenotype analysis.揭示胚胎间纺锤体长度随时间的变化:迈向定量表型分析。
PLoS Comput Biol. 2024 Sep 5;20(9):e1012330. doi: 10.1371/journal.pcbi.1012330. eCollection 2024 Sep.
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The spindle protein CKAP2 regulates microtubule dynamics and ensures faithful chromosome segregation.纺锤体蛋白 CKAP2 调节微管动力学,确保染色体的正确分离。
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