El Jashi Rima, Gustafson Maria B, Jakobsen Mette B, Lautrup Charlotte, Hertz Jens M, Søballe Kjeld, Mechlenburg Inger
Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus - Denmark.
Department of Clinical Genetics, Aalborg University Hospital, Aalborg - Denmark.
Hip Int. 2017 May 12;27(3):299-304. doi: 10.5301/hipint.5000461. Epub 2017 Feb 3.
The development of hip dysplasia is associated with several risk factors. 1 of these risk factors is gender, since 80% of patients with symptomatic hip dysplasia are females. Another risk factor for hip dysplasia is familial predisposition of hip dysplasia. Several studies indicate that the risk of hip dysplasia is increased with familial prevalence of hip dysplasia. However, little is known about the association between the familial prevalence and gender and the development of hip dysplasia.
The aim of the study was to estimate the prevalence of hip dysplasia among relatives to Danish patients with hip dysplasia operated with periacetabular osteotomy (PAO), and the degree of relationship of affected family members. Furthermore, to assess the association between gender and family predisposition in the same group of patients.
The study is a cross-sectional study, with a descriptive and an analytical part. The study population consists of 676 patients drawn from a clinical database of patients operated with PAO at Aarhus University hospital from 1998 to 2014. Information about gender, operated hip side and age was collected from the clinical PAO database, while information about familial prevalence was collected through questionnaires. The association between gender and familial prevalence of hip dysplasia was presented as the prevalence proportions ratio (PPR), tested by χ2 test. Stratification was conducted for the variables age and operated hip side, with the Mantel-Haenszels analytical method, and tested for statistical significance by χ2.
The familial prevalence of hip dysplasia in the study population was 30% (95% CI, 27%-34%), with 73% reporting affected first-degree relatives. Females have 32% increased risk of familial prevalence of hip dysplasia compared to males, but this difference in risk was not statistically significant (p = 0.10).
The study shows that females have 32% increased familial prevalence of hip dysplasia compared to males, but the increased prevalence was not statistically significant probably due to the low power of the study.
髋关节发育不良的发生与多种风险因素相关。其中一个风险因素是性别，因为80%有症状的髋关节发育不良患者为女性。髋关节发育不良的另一个风险因素是髋关节发育不良的家族易感性。多项研究表明，随着髋关节发育不良家族患病率的增加，髋关节发育不良的风险也会升高。然而，关于家族患病率与性别以及髋关节发育不良发生之间的关联却知之甚少。
本研究的目的是评估丹麦接受髋臼周围截骨术（PAO）治疗的髋关节发育不良患者亲属中髋关节发育不良的患病率，以及受影响家庭成员之间的亲缘关系程度。此外，评估同一组患者中性别与家族易感性之间的关联。
本研究为横断面研究，包括描述性和分析性两部分。研究人群包括从奥胡斯大学医院1998年至2014年接受PAO手术的患者临床数据库中抽取的676例患者。从PAO临床数据库中收集性别、手术髋关节侧别和年龄信息，而家族患病率信息则通过问卷调查收集。髋关节发育不良的性别与家族患病率之间的关联以患病率比例比（PPR）表示，通过χ²检验进行检验。采用Mantel-Haenszels分析方法对年龄和手术髋关节侧别变量进行分层，并通过χ²检验其统计学意义。
研究人群中髋关节发育不良的家族患病率为30%（95%CI，27%-34%），73%的人报告有一级亲属受影响。与男性相比，女性家族性髋关节发育不良患病率的风险增加32%，但这种风险差异无统计学意义（p = 0.10）。
该研究表明，与男性相比，女性家族性髋关节发育不良患病率增加32%，但患病率增加可能因研究效能低而无统计学意义。
