Oliveira Rui Caetano, Amaro Pedro, Julião Maria José, Cipriano Maria Augusta
Department of Pathology, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
Department of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
BMJ Case Rep. 2017 Feb 6;2017:bcr2016218967. doi: 10.1136/bcr-2016-218967.
Extramedullary plasmacytomas (EP) are tumours composed by a monoclonal population of plasma cells that arise in extraosseus tissues, comprising <5% of all plasma cell neoplasms. Usually, EP arise in the head and neck region, and the stomach is the second most common location-gastric plasmacytoma (GP). Clinical and radiological manifestations are unspecific and may mimic other tumours like gastric adenocarcinomas, gastric stromal tumours and lymphomas, mainly marginal cell lymphoma (MALT lymphoma) and usually definitive diagnosis is provided by pathological evaluation. We present a case of primary GP, discovered incidentally as a polypoid lesion. Tumour was composed by sheets of mature and immature plasmocytes positive for CD138 on immunohistochemistry, without Helicobacter pylori identification. The patient is alive 6 years later and without tumour relapse.
髓外浆细胞瘤（EP）是由单克隆浆细胞群体组成的肿瘤，发生于骨外组织，占所有浆细胞肿瘤的比例小于5%。通常，EP发生于头颈部区域，胃是第二常见的发病部位——胃浆细胞瘤（GP）。其临床和影像学表现不具有特异性，可能与其他肿瘤相似，如胃腺癌、胃间质瘤和淋巴瘤，主要是边缘区细胞淋巴瘤（MALT淋巴瘤），通常通过病理评估来明确诊断。我们报告一例原发性GP，偶然发现为息肉样病变。肿瘤由免疫组化显示CD138阳性的成片成熟和不成熟浆细胞组成，未发现幽门螺杆菌。6年后患者仍存活，且无肿瘤复发。
