Cherry F F, Sandstead H H, Rojas P, Johnson L K, Batson H K, Wang X B
Department of Applied Health Sciences, Tulane University Medical Center, New Orleans.
Am J Clin Nutr. 1989 Nov;50(5):945-54. doi: 10.1093/ajcn/50.5.945.
In a double-blind zinc trial in low-income, pregnant adolescents thought to be at risk for poor zinc nutriture, subjects were randomly assigned to receive 30 mg zinc (gluconate) or placebo. Response to zinc was related to maternal weight. Infants of normal-weight mothers given zinc had reduced rates of prematurity (p = 0.05) and assisted respiration (p = 0.006). Underweight multiparas given zinc had longer gestational lengths (p = 0.008) than did subjects given the placebo. Multiple stepwise regression analysis, used to identify predictors of infant size, revealed that 14-26% more variance was accounted for in the zinc than in the placebo group. Except for gestational age, the predictors selected were entirely different in the two groups. The zinc group had a positive toxemia screen more often, which did not appear to affect outcome. Zinc supplementation improved pregnancy outcome in normal-weight women and in underweight multiparas. The nonresponse in underweight primiparas was perhaps due to multiple limiting factors.
在一项针对被认为有锌营养不良风险的低收入怀孕青少年的双盲锌试验中，受试者被随机分配接受30毫克锌（葡萄糖酸锌）或安慰剂。对锌的反应与母亲体重有关。给正常体重母亲补充锌后，其婴儿的早产率（p = 0.05）和辅助呼吸率（p = 0.006）降低。给体重过轻的经产妇补充锌后，其孕周比接受安慰剂的受试者更长（p = 0.008）。用于确定婴儿大小预测因素的多元逐步回归分析显示，锌组比安慰剂组多解释了14 - 26%的方差。除了孕周外，两组选择的预测因素完全不同。锌组的毒血症筛查呈阳性的情况更常见，但这似乎并未影响结果。补充锌改善了正常体重妇女和体重过轻经产妇的妊娠结局。体重过轻初产妇无反应可能是由于多种限制因素。
