Saaka Mahama, Oosthuizen Jacques, Beatty Shelley
School of Exercise, Biomedical and Health Sciences, Edith Cowan University, 100 Joondalup Drive, Joondalup, WA 6027, Australia.
J Health Popul Nutr. 2009 Oct;27(5):619-31. doi: 10.3329/jhpn.v27i5.3638.
Although iron and zinc deficiencies are known to occur together and also appear to be high in Ghana, a few supplementation studies addressed this concurrently in pregnancy. In a double-blind, randomized controlled trial, 600 pregnant women in Ghana were randomly assigned to receive either a combined supplement of 40 mg of zinc as zinc gluconate and 40 mg of iron as ferrous sulphate or 40 mg of elemental iron as ferrous sulphate. Overall, there was no detectable difference in the mean birthweight between the study groups, although the effect of iron-zinc supplementation on the mean birthweight was masked by a strong interaction between the type of supplement and the iron status of participants [F (1,179) = 5.614, p = 0.019]. Prenatal iron-zinc supplementation was effective in increasing the mean birthweight among anaemic and iron-deficient women but not among women with elevated iron stores in early pregnancy.
虽然已知缺铁和缺锌会同时出现，而且在加纳似乎也很普遍，但在孕期很少有补充剂研究同时针对这两种情况。在一项双盲随机对照试验中，加纳的600名孕妇被随机分配，分别接受含有40毫克葡萄糖酸锌和40毫克硫酸亚铁的复合补充剂，或者只接受40毫克硫酸亚铁形式的元素铁。总体而言，研究组之间的平均出生体重没有明显差异，不过补充剂类型与参与者铁状态之间的强烈相互作用掩盖了铁锌补充剂对平均出生体重的影响[F(1,179)=5.614，p=0.019]。产前补充铁锌对贫血和缺铁妇女的平均出生体重有增加作用，但对孕早期铁储备较高的妇女则没有效果。
