Cheki Mohsen, Mihandoost Ehsan, Shirazi Alireza, Mahmoudzadeh Aziz
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology and Medical Physics, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
J Cancer Res Ther. 2016 Oct-Dec;12(4):1234-1242. doi: 10.4103/0973-1482.172131.
Genotoxicity in lymphocytes of cancer patients undergoing radiotherapy can lead to lymphocytopenia. Lymphocytopenia induced by radiotherapy is one of the most unfavorable prognostic biological markers in cancer patients, since it has been accepted to be associated with poor prognosis in terms of both survival time and response to cancer therapy. Therefore, reduction in lymphocytopenia may increase treatment efficiency. Research endeavors with synthetic radioprotectors in the past have met with little success primarily due to toxicity-related problems. These disadvantages have led to interest on the use of some plants and phytochemicals as radioprotector. The aim of this paper is to review protective role of some plants and phytochemicals against genotoxicity-induced by ionizing radiation in human blood lymphocytes. Therefore, current review may help the future researches to decrease lymphocytopenia in radiotherapeutic clinical trials.
接受放射治疗的癌症患者淋巴细胞中的遗传毒性可导致淋巴细胞减少。放射治疗引起的淋巴细胞减少是癌症患者中最不利的预后生物学标志物之一，因为在生存时间和对癌症治疗的反应方面，它都被认为与预后不良有关。因此，减少淋巴细胞减少可能会提高治疗效率。过去使用合成辐射防护剂的研究努力主要由于毒性相关问题而收效甚微。这些缺点引发了人们对使用某些植物和植物化学物质作为辐射防护剂的兴趣。本文的目的是综述某些植物和植物化学物质对电离辐射诱导的人体血液淋巴细胞遗传毒性的保护作用。因此，当前的综述可能有助于未来的研究在放射治疗临床试验中减少淋巴细胞减少。
