Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane Innovation Park, Nathan, Qld 4111, Australia.
Chem Asian J. 2012 Jan 2;7(1):22-35. doi: 10.1002/asia.201100780. Epub 2011 Dec 8.
In the long lasting battle against cancer, Nature sometimes gives a helping hand to researchers to find new drugs for the treatment of diseases and improvement of patients' well-being. Englerin A has emerged as a promising anticancer candidate as well as being an exciting synthetic challenge for organic chemists. This focus review summarizes the total syntheses reported to date and the synthetic approaches toward analogues of this fascinating natural product.
在与癌症的长期斗争中，大自然有时会为研究人员提供帮助，找到治疗疾病和改善患者福祉的新药。Englerin A 不仅是一种很有前途的抗癌候选药物，也是有机化学家面临的一项令人兴奋的合成挑战。本综述总结了迄今为止报道的全合成以及该迷人天然产物类似物的合成方法。
