WISP-1在多种病理过程中的双重作用。
Dual effect of WISP-1 in diverse pathological processes.
作者信息
Feng Mengmeng, Jia Shuqin
机构信息
Laboratory of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China.
Laboratory of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Molecular Oncology Laboratory, Peking University Cancer Hospital & Institute, Beijing 100142, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Molecular Diagnosis, Peking University Cancer Hospital & Institute, Beijing 100142, China.
出版信息
Chin J Cancer Res. 2016 Dec;28(6):553-560. doi: 10.21147/j.issn.1000-9604.2016.06.01.
Wnt-1 inducible signaling pathway-1 (WISP-1), also known as CCN-4, belongs to the connective tissue growth factor (CTGF) family. WISP-1 is primarily expressed in embryonic stem cells and is involved in adult organ development. WISP-1 participates in many cellular processes, including proliferation, differentiation, apoptosis and adhesion. In addition, WISP-1 plays an important role in diverse pathophysiological processes, such as embryonic development, inflammation, injury repairs and cancers. Recent studies showed that WISP-1 was highly correlated with tumor progression and malignant transformation, whereas it played an oncogenic role in colorectal cancer, cholangiocarcinoma, hepatocellular carcinoma and breast cancer. However, interestingly, WISP-1 exerts a tumor-suppressing role in lung and prostate cancers. WISP-1 promotes cell proliferation, adhesion, motility, invasion, metastasis and epithelial-to-mesenchymal transition via particular signaling pathways. In this review, we discussed the structure, expression profile, functions, clinical significance and potential mechanisms of WISP-1 in cancer and non-neoplastic diseases.
Wnt-1诱导信号通路蛋白1（WISP-1），也称为CCN-4，属于结缔组织生长因子（CTGF）家族。WISP-1主要在胚胎干细胞中表达，并参与成体器官发育。WISP-1参与许多细胞过程，包括增殖、分化、凋亡和黏附。此外，WISP-1在多种病理生理过程中发挥重要作用，如胚胎发育、炎症、损伤修复和癌症。最近的研究表明，WISP-1与肿瘤进展和恶性转化高度相关，而它在结直肠癌、胆管癌、肝细胞癌和乳腺癌中发挥致癌作用。然而，有趣的是，WISP-1在肺癌和前列腺癌中发挥肿瘤抑制作用。WISP-1通过特定的信号通路促进细胞增殖、黏附、运动、侵袭、转移和上皮-间质转化。在本综述中，我们讨论了WISP-1在癌症和非肿瘤性疾病中的结构、表达谱、功能、临床意义及潜在机制。
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