Feng Mengmeng, Jia Shuqin
Laboratory of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China.
Laboratory of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Molecular Oncology Laboratory, Peking University Cancer Hospital & Institute, Beijing 100142, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Molecular Diagnosis, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Chin J Cancer Res. 2016 Dec;28(6):553-560. doi: 10.21147/j.issn.1000-9604.2016.06.01.
Wnt-1 inducible signaling pathway-1 (WISP-1), also known as CCN-4, belongs to the connective tissue growth factor (CTGF) family. WISP-1 is primarily expressed in embryonic stem cells and is involved in adult organ development. WISP-1 participates in many cellular processes, including proliferation, differentiation, apoptosis and adhesion. In addition, WISP-1 plays an important role in diverse pathophysiological processes, such as embryonic development, inflammation, injury repairs and cancers. Recent studies showed that WISP-1 was highly correlated with tumor progression and malignant transformation, whereas it played an oncogenic role in colorectal cancer, cholangiocarcinoma, hepatocellular carcinoma and breast cancer. However, interestingly, WISP-1 exerts a tumor-suppressing role in lung and prostate cancers. WISP-1 promotes cell proliferation, adhesion, motility, invasion, metastasis and epithelial-to-mesenchymal transition via particular signaling pathways. In this review, we discussed the structure, expression profile, functions, clinical significance and potential mechanisms of WISP-1 in cancer and non-neoplastic diseases.
Wnt-1诱导信号通路蛋白1（WISP-1），也称为CCN-4，属于结缔组织生长因子（CTGF）家族。WISP-1主要在胚胎干细胞中表达，并参与成体器官发育。WISP-1参与许多细胞过程，包括增殖、分化、凋亡和黏附。此外，WISP-1在多种病理生理过程中发挥重要作用，如胚胎发育、炎症、损伤修复和癌症。最近的研究表明，WISP-1与肿瘤进展和恶性转化高度相关，而它在结直肠癌、胆管癌、肝细胞癌和乳腺癌中发挥致癌作用。然而，有趣的是，WISP-1在肺癌和前列腺癌中发挥肿瘤抑制作用。WISP-1通过特定的信号通路促进细胞增殖、黏附、运动、侵袭、转移和上皮-间质转化。在本综述中，我们讨论了WISP-1在癌症和非肿瘤性疾病中的结构、表达谱、功能、临床意义及潜在机制。
