Peralta-Aros Carolina, García-Nieto Víctor
Hospital Uyapar, Puerto Ordaz, Venezuela.
Pediatric Nephrology Service, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Canary Islands, Spain.
Pediatr Nephrol. 2017 May;32(5):897-900. doi: 10.1007/s00467-017-3588-5. Epub 2017 Feb 7.
Zika is an emerging mosquito-borne flavivirus. We report two pediatric patients diagnosed with idiopathic nephrotic syndrome who achieved complete remission of the disease after suffering Zika virus (ZIKV) infection.
CASE DIAGNOSIS/TREATMENT: The first patient was a young girl aged 2.5 years with steroid-dependent nephrotic syndrome who was subsequently diagnosed with ZIKV infection. Following the infection, the steroid dose could be reduced until complete withdrawal. The patient persists in complete remission. The second patient was a steroid-resistant boy aged 7 years who was scheduled for a renal biopsy when he was diagnosed with ZIKV infection. A week after the recovery phase of the acute rash, proteinuria was noted to be gradually falling. Today, 12 months later, he is in complete remission of the disease.
We are aware that the improvement observed in our two patients after ZIKV infection may be be random. However, it is also possible that future studies will discover that ZIKV infection has some effect on the cellular immune system similar to that of measles infection.
寨卡病毒是一种新出现的经蚊子传播的黄病毒。我们报告了两名被诊断为特发性肾病综合征的儿科患者，他们在感染寨卡病毒（ZIKV）后疾病完全缓解。
病例诊断/治疗：首例患者是一名2.5岁的患有类固醇依赖型肾病综合征的小女孩，随后被诊断为ZIKV感染。感染后，类固醇剂量可逐渐减少直至完全停用。该患者持续完全缓解。第二例患者是一名7岁的类固醇抵抗型男孩，在被诊断为ZIKV感染时正计划进行肾活检。急性皮疹恢复期一周后，发现蛋白尿逐渐减少。12个月后的今天，他的疾病已完全缓解。
我们意识到，在我们的两名患者感染ZIKV后观察到的病情改善可能是偶然的。然而，未来的研究也有可能发现ZIKV感染对细胞免疫系统有一些类似于麻疹感染的影响。
